Cancer-related activity sensors

Abstract

An activity sensor sensitive to enzymes indicative of the presence of cancer is used to provide non-invasive reporting of tumor development and response to anticancer therapies useful in determining suitability and effectiveness of various treatments including immuno-oncological therapies. Localized reporters are used in patient stratification in clinical trials, monitoring of drug response or disease progression, and differentiating between anti-tumor immune response, tumor progression, and off-target immune response. Activity sensors may include tuning domains to modulate tissue localization and residency. Periodic measurements of activity sensor reporters may be analyzed to determine a velocity value indicative of disease prognosis.

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