Identification and treatment of tumors characterized by an overexpression of the neonatal fc receptor
AssigneesAarhus Universitet, Albumedix Ltd
InventorsKenneth Alan Howard, Jason Cameron, Maja Thim Larsen, Frederik Dagnæs-Hansen
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Abstract
In a first aspect, the invention relates to the identification of cancer types over-expressing the FcRn receptor. In a second aspect, the invention relates to the treatment of said cancer types. In further aspects, the invention relates to identification of subtypes of inflammatory diseases and treatments thereof. In an additional aspect, the invention relates to in vivo imaging of cancers over-expressing the FcRn receptor.
Claims22
A method of subtyping a cancer, staging a cancer, or predicting the risk of developing a cancer, the method comprising:
- providing a biological sample from a subject;
- measuring the level of FcRn in said sample;
- and
- comparing said measured level to a reference level;
- wherein a higher level of FcRn in said sample compared to the reference level is indicative of an FcRn up-regulated subtype/stage;
- and wherein a level equal to or lower than said reference level is indicative of an FcRn normal subtype/stage or FcRn down-regulated subtype/stage;
- or
- wherein a higher level of FcRn in said sample compared to the reference level is indicative of an increased risk of developing a cancer;
- and wherein a level equal to or lower than said reference level is not indicative of an increased risk of developing a cancer.
2-34. (canceled)
A method for treating a subject having a cancer over-expressing FcRn, the method comprising administering to the subject an FcRn binding agent coupled to a therapeutic agent.
A method for in vivo imaging a subject having a cancer over-expressing FcRn, the method comprising:
- a) administering to the subject an FcRn binding agent coupled to a detectable moiety, and
- b) imaging the subject to detect said FcRn binding agent coupled to a detectable moiety bound to the cancer over-expressing FcRn.
Dependencies are inferred from the claim text.