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US 2021/0333263 A1Published application
Redox activatable fluorescent sensors
OwnerJinming GAO, Zhaohui WANG +3inventors
InventorsJinming GAO, Zhaohui WANG, Min LUO, Qi WEI, Gang HUANG
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Abstract
Provided herein are compounds of the formula: (I) wherein the variables are defined herein, which may be used as redox-activatable sensors. In some aspects, the compounds are fluorescence sensors which are activated by the redox state of the cell. Also provided herein are methods of using these compounds to image the cellular environment or the delivery of macromolecules to a cell.
Claims28
A compound of the formula:
- wherein:
- R1 is a first label, amino, hydroxy, alkoxy(C≤8), substituted alkoxy(C≤8), alkylamino(C≤8), substituted alkylamino(C≤8), dialkylamino(C≤8), substituted dialkylamino(C≤8), an amine reactive group;
- a thiol reactive group, an organic polymer, a nucleic acid sequence, a peptide, or a protein;
- R2 is a first label, hydrogen, alkyl(C≤8), substituted alkyl(C≤8), an organic polymer, a nucleic acid sequence, a peptide, or a protein;
- R3 is a second label;
- and
- m and n are each independently 0, 1, 2, or 3;
- provided that either R1 or R2 is a first label.
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Dependencies are inferred from the claim text.