Visual indicators of biospecimen time-temperature exposure
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsChad Borges, Kazi Waheeda
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Abstract
An indicator system comprising permanganate, an organic reducing agent, an acid, and optionally an inorganic salt is provided herein, as well as methods for using the indicator system for monitoring the integrity of a biospecimen are provided herein.
Claims20
An indicator system comprising permanganate, an organic reducing agent, an acid, an aqueous solvent, and optionally an inorganic salt initially configured to prevent reduction of the permanganate to Mn2+,
- wherein a mixture of the permanganate, the organic reducing agent, the acid, the aqueous solvent, and, if present, the inorganic salt is an eutectic composition having a predetermined freezing point, and
- wherein when above the predetermined freezing point the mixture is a liquid and the organic reducing agent causes a reduction reaction of permanganate to Mn2+ and when below the predetermined freezing point the mixture is a solid and the reduction reaction is stopped.
The indicator system of claim 8, wherein the indicator system comprises between 15% and 30% by weight of the inorganic salt and wherein the predetermined freezing point is less than −15.0° C.
Dependencies are inferred from the claim text.