siNA MOLECULES, METHODS OF PRODUCTION AND USES THEREOF
AssigneePhyzat Biopharmaceuticals, Lda.
InventorPATRICIO MANUEL VIEIRA ARAUJO SOARES DA SILVA
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Abstract
The present disclosure relates to method of producing and using short interfering nucleic acids (siNAs) for preventing and treating coronavirus-inflicted infectious conditions. In particular, this disclosure relates to the method of producing and using siNAs for preventing and treating infections by the coronavirus SARS-CoV-2, the causative viral agent of the novel coronavirus disease COVID-19, to mediate gene silencing of viral proteins. The present disclosure is also directed to interfering RNA duplexes and vectors encoding such interfering RNA duplexes.
Claims19
An isolated or synthetic siNA (short interfering nucleic acid) molecule, wherein said molecule comprises a nucleic acid sequence selected from the group consisting of:
- SEQ ID No 340 to SEQ ID No 678, preferably SEQ ID No 374, SEQ ID No 375, SEQ ID No 452, SEQ ID No 453, SEQ ID No 500, SEQ ID No 501, SEQ ID No 520, SEQ ID No 556, SEQ ID No 562, SEQ ID No 563, SEQ ID No 565, SEQ ID No 566, SEQ ID No 569, SEQ ID No 570, SEQ ID No 642, SEQ ID No 643, SEQ ID No 644, SEQ ID No 646, SEQ ID No 647, SEQ ID No 648, SEQ ID No 666 to SEQ ID No 668, SEQ ID No 672, SEQ ID No 676 and SEQ ID No 677, more preferably SEQ ID No 375, SEQ ID No 452, SEQ ID No 500, SEQ ID No 501, SEQ ID No 520, SEQ ID No 556, SEQ ID No 563, SEQ ID No 566, SEQ ID No 648, SEQ ID No 666, SEQ ID No 668, SEQ ID No 671, SEQ ID No 672, SEQ ID No 676, SEQ ID No 677, and variants thereof.
Dependencies are inferred from the claim text.