Anti-human tlr7 antibody

A polynucleotide comprising a polynucleotide sequence encoding an antibody or an antigen-binding fragment of the antibody, wherein the antibody or an antigen-binding fragment of the antibody having the properties of:

• (a) specifically binding to human TLR7 or monkey TLR7 and not binding to mouse TLR7 or rat TLR7;
• (b) inhibiting a function of human TLR7 or monkey TLR7;
• and
• (c) comprising CDRH1 consisting of the amino acid sequence set forth in SEQ ID NO:
• 17, CDRH2 consisting of the amino acid sequence set forth in SEQ ID NO:
• 18 and CDRH3 consisting of the amino acid sequence set forth in SEQ ID NO:
• 19, as complementarity determining regions in the heavy chain, and CDRL1 consisting of the amino acid sequence set forth in SEQ ID NO:
• 20, CDRL2 consisting of the amino acid sequence set forth in SEQ ID NO:
• 21 and CDRL3 consisting of the amino acid sequence set forth in SEQ ID NO:
• 22, as complementarity determining regions in the light chain.