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US 2021/0332145 A1Published application
Anti-bcma antibodies
AssigneesSingle Cell Technology, Inc., ACROBiosystems, Inc.
InventorsLeyan TANG, Allison SCHULKINS, Kimberly THAN, Chun-Nan CHEN, Jingyun MIAO, Xiaohui ZHANG, Xiaojuan SHI, Lin ZHANG
Life of this patent
Estimating the term…
Abstract
Provided are antibodies that recognize the B-Cell Maturation Antigen (BCMA) and methods of use thereof.
Claims26
An antibody that binds human BCMA (SEQ ID NO:1) comprising:
- a) a HCDR1 having the amino acid sequence of SEQ ID NO:50, a HCDR2 having the amino acid sequence of SEQ ID NO:76, a HCDR3 having the amino acid sequence of SEQ ID NO:94, a LCDR1 having the amino acid sequence of SEQ ID NO:61, a LCDR2 having the amino acid sequence of SEQ ID NO:85, and a LCDR3 having the amino acid sequence of SEQ ID NO:105;
- or
- b) a HCDR1 having the amino acid sequence of SEQ ID NO:50, a HCDR2 having the amino acid sequence of SEQ ID NO:76, a HCDR3 having the amino acid sequence of SEQ ID NO:95, a LCDR1 having the amino acid sequence of SEQ ID NO:61, a LCDR2 having the amino acid sequence of SEQ ID NO:85, and a LCDR3 having the amino acid sequence of SEQ ID NO:106;
- or
- c) a HCDR1 having the amino acid sequence of SEQ ID NO:50, a HCDR2 having the amino acid sequence of SEQ ID NO:76, a HCDR3 having the amino acid sequence of SEQ ID NO:96, a LCDR1 having the amino acid sequence of SEQ ID NO:61, a LCDR2 having the amino acid sequence of SEQ ID NO:85, and a LCDR3 having the amino acid sequence of SEQ ID NO:107;
- or
- d) a HCDR1 having the amino acid sequence of SEQ ID NO:50, a HCDR2 having the amino acid sequence of SEQ ID NO:76, a HCDR3 having the amino acid sequence of SEQ ID NO:97, a LCDR1 having the amino acid sequence of SEQ ID NO:61, a LCDR2 having the amino acid sequence of SEQ ID NO:85, and a LCDR3 having the amino acid sequence of SEQ ID NO:107;
- or
- e) a HCDR1 having the amino acid sequence of SEQ ID NO:46, a HCDR2 having the amino acid sequence of SEQ ID NO:72, a HCDR3 having the amino acid sequence of SEQ ID NO:90, a LCDR1 having the amino acid sequence of SEQ ID NO:57, a LCDR2 having the amino acid sequence of SEQ ID NO:82, and a LCDR3 having the amino acid sequence of SEQ ID NO:101;
- or
- f) a HCDR1 having the amino acid sequence of SEQ ID NO:48, a HCDR2 having the amino acid sequence of SEQ ID NO:74, a HCDR3 having the amino acid sequence of SEQ ID NO:92, a LCDR1 having the amino acid sequence of SEQ ID NO:59, a LCDR2 having the amino acid sequence of SEQ ID NO:84, and a LCDR3 having the amino acid sequence of SEQ ID NO:103.
8 more elements
An antibody that binds human BCMA (SEQ ID NO:1) comprising:
- a) a VH having the amino acid sequence of SEQ ID NO:6, and a VL having the amino acid sequence of SEQ ID NO:7;
- or
- b) a VH having the amino acid sequence of SEQ ID NO:8, and a VL having the amino acid sequence of SEQ ID NO:9;
- or
- c) a VH having the amino acid sequence of SEQ ID NO:10, and a VL having the amino acid sequence of SEQ ID NO:11;
- or
- d) a VH having the amino acid sequence of SEQ ID NO:12, and a VL having the amino acid sequence of SEQ ID NO:13;
- or
- e) a VH having the amino acid sequence of SEQ ID NO:33, and a VL having the amino acid sequence of SEQ ID NO:34;
- or
- f) a VH having the amino acid sequence of SEQ ID NO:37, and a VL having the amino acid sequence of SEQ ID NO:38.
8 more elements
An antibody that binds human BCMA (SEQ ID NO:1) comprising:
- a) a heavy-chain comprising the amino acid sequence of SEQ ID NO:6 and a light-chain comprising the amino acid sequence of SEQ ID NO:7;
- or
- b) a heavy-chain comprising the amino acid sequence of SEQ ID NO:8 and a light-chain comprising the amino acid sequence of SEQ ID NO:9;
- or
- c) a heavy-chain comprising the amino acid sequence of SEQ ID NO:10 and a light-chain comprising the amino acid sequence of SEQ ID NO:11;
- or
- d) a heavy-chain comprising the amino acid sequence of SEQ ID NO:12 and a light-chain comprising the amino acid sequence of SEQ ID NO:13;
- or
- e) a heavy-chain comprising the amino acid sequence of SEQ ID NO:33 and a light-chain comprising the amino acid sequence of SEQ ID NO:34;
- or
- f) a heavy-chain comprising the amino acid sequence of SEQ ID NO:37 and a light-chain comprising the amino acid sequence of SEQ ID NO:38.
8 more elements
Dependencies are inferred from the claim text.