Human antibody-producing cell

Abstract

A chicken B cell that expresses a variety of human antibodies. A chicken B cell, in which, in an antibody light chain gene locus thereof, all or a part of a DNA sequence derived from a human antibody light chain variable region and a human antibody light chain constant region are inserted, or the antibody light chain gene locus is replaced with all or a part of a DNA sequence derived from human antibody light chain variable and constant regions, and in an antibody heavy chain gene locus thereof, all or a part of a DNA sequence derived from human antibody heavy chain variable and constant regions are inserted, or the antibody heavy chain gene locus is replaced with all or a part of a DNA sequence derived from human antibody heavy chain variable and constant regions, and in an antibody light chain pseudogene locus thereof, two or more DNA sequences derived from human antibody light chain variable regions are inserted, or the antibody light chain pseudogene locus is replaced with two or more DNA sequences derived from human antibody light chain variable regions, and/or in an antibody heavy chain pseudogene locus thereof, two or more DNA sequences derived from human antibody heavy chain variable regions are inserted, or the antibody heavy chain pseudogene locus is replaced with two or more DNA sequences derived from human antibody heavy chain variable regions.

Dependencies are inferred from the claim text.