Antibodies to zika virus and methods of use thereof
AssigneeWashington University
InventorsMichael S. Diamond, Daved Fremont, Haiyan Zhao, Estefania Fernandez, Derek Platt, Christopher Nelson
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Abstract
The present disclosure relates to antibodies specific to Zika virus and methods for detecting Zika virus infection in a subject. The present disclosure also relates to therapeutic antibodies useful in reducing viral load.
Claims30
An isolated antigen binding protein that specifically binds the lateral ridge (LR) or the CC′ loop within domain III (DIII) of the E protein of Zika virus.
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A method of treating a Zika virus infection in a subject, the method comprising administering to the subject an effective amount of an isolated antigen binding protein, wherein the antigen binding protein specifically binds the lateral ridge (LR) or the CC′ loop within domain III (DIII) of the E protein of Zika virus.
A method of protecting against a Zika virus infection in a subject, the method comprising administering to the subject an effective amount of an isolated antigen binding protein, wherein the antigen binding protein specifically binds the lateral ridge (LR) or the CC′ loop within domain III (DIII) of the E protein of Zika virus.
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Dependencies are inferred from the claim text.