Tetrahydropyridopyrimidine derivatives as ahr modulators

A compound of formula (I)

• wherein:
• Y is a 5 or 6 membered ring optionally comprising 1, 2, or 3 heteroatoms selected from N, O and S, substituted with R5 and R6;
• R1 is H, C1-3 alkyl, (—CH2)pCN, —COC1-3 alkyl, —CO(CH2)qNR7R8, —SO2C1-3 alkyl,
• —SO2NR7R8, —(CH2)qPh, −, —C(O)Z;
• R2 is H or C1-3 alkyl;
• R3 is H or C1-3 alkyl;
• R4 is a-9 or 10 membered heteroaryl with at least one heteroatom selected from N, O or S (Indol-3-yl or Benzimidazol-2-yl), with substituents R9 and R10;
• R5 is H, hydroxy, halogen (such as F, Cl), CN or a C1-3 alkyl group, —CO(CH2)qNR7R8,
• —SO2C1-3 alkyl, —SO2NR7R8;
• R6 is hydroxy, halogen (such as F, Cl), CN or a C1-3 alkyl group, —CO(CH2)qNR7R8,
• —SO2C1-3 alkyl, —SO2NR7R8;
• R7 is H or C1-3 alkyl, such as —CH3;
• R8 is H or C1-3 alkyl, such as —CH3;
• R9 is H, hydroxy, halogen (such as F, Cl), CN or a C1-3 alkyl group, —CO(CH2)q NR7R8,
• —SO2C1-3 alkyl, —SO2NR7R8,
• R10 is H, hydroxy, halogen (such as F, Cl), CN or a C1-3 alkyl group, —CO(CH2)q NR7R8,
• —SO2C1-3 alkyl, —SO2NR7R8;
• R11 is H or C1-3 alkyl, such as —CH3;
• X is NR11 or O;
• Z is a 5 or 6 membered heteroaryl (i.e. with at least one heteroatom selected from N, O and S, for example 1 or 2 nitrogens) optionally bears one or two substituents selected from hydroxy, halogen (such as F, Cl), CN, C1-3 alkyl;
• b is an integer 1 or 2;
• n is an integer 1 or 2;
• m is an integer 1 or 2;
• p is an integer 1, 2 or 3;
• q is 0, 1, 2 or 3,
• or a pharmaceutically acceptable salt thereof.