Synthesis and anti-tumor activities of acyl-para-aminophenol derivatives
AssigneeMontefiore Medical Center
InventorsParviz LALEZARI, Rukmani LEKHARJ, Alex LUNA, Diana CASPER
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Abstract
Method are disclosed for synthesizing derivatives of acyl-para-aminophenol and for the use of the compounds for treating lymphomas and tumors of the brain and spinal cord.
Claims36
A method of synthesizing an acyl-para-aminophenol derivative, the method comprising:
- i) dissolving para-aminophenol (PAP) in a solvent to form a PAP solution;
- ii) adding a base to the PAP solution to form a PAP-base solution;
- iii) adding an acylating agent to the PAP-base solution to form a solution comprising base and PAP precipitates and the acyl-para-aminophenol derivative;
- iv) removing the base and PAP precipitates from the solution;
- and
- v) retrieving the acyl-para-aminophenol derivatives from the solution.
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A method of treating a brain or spinal cord tumor or a lymphoma in a subject comprising administering to the subject a compound of formula (I) in an amount and manner effective to inhibit the growth of the tumor cells, wherein the compound of formula (I) has the structure:
- wherein R is a C2-C15 straight chain or branched alkyl, alkenyl, or alkynyl, or a cycloalkyl, heterocycloalky, aryl, heteroaryl, aralkyl, or heteroaralkyl.
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Dependencies are inferred from the claim text.