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AssigneeSio2 Medical Products, Inc.
InventorsChristopher Weikart, John T. Felts, Thomas E. Fisk, Robert S. Abrams, John Ferguson, Jonathan R. Freedman, Robert J. Pangborn, Peter J. Sagona
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A vessel including a thermoplastic wall enclosing a lumen is disclosed. The wall supports an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, between the wall and the lumen. High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the wall or substrate. In one aspect, the interface has at least 1 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding. In another aspect, the interface has an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiO4 bonding. The result is a tightly adherent composite barrier coating or layer having a high degree of adhesion to the substrate under practical use conditions. Methods of applying the composite barrier coating or layer are also disclosed.
A vessel comprising a thermoplastic wall enclosing a lumen and an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, supported by the wall between the wall and the lumen, in which the SiOx composite barrier coating or layer is formed by PECVD from an organosilicon monomer and oxidizing gas, in at least bonding and buildup stages, under the following conditions:
A vessel comprising a thermoplastic wall enclosing a lumen and an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, supported by the wall between the wall and the lumen, in which the SiOx composite barrier coating or layer is formed by RF PECVD from an organosilicon monomer and oxidizing gas, at an initial RF power level from 20 to 4 W and a highest RF power level of from 300 to 30 W.
A vessel comprising a thermoplastic wall enclosing a lumen and an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, supported by the wall between the wall and the lumen, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 95% by the Article Deformation/Tape Test Method.
A vessel comprising a thermoplastic wall enclosing a lumen and an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, supported by the wall between the wall and the lumen, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 90% by the Coated Article Cross-Scratch Tape Test Method.
A vessel comprising a thermoplastic wall enclosing a lumen and an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, supported by the wall between the wall and the lumen, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 1 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
A vessel comprising a thermoplastic wall enclosing a lumen and an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, supported by the wall between the wall and the lumen, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiO4 bonding.
A method of making a vessel comprising:
A method of making a vessel comprising:
A method of making a vessel comprising:
A method of making a vessel comprising:
A method of making a vessel comprising:
A method of making a vessel comprising:
The invention of any preceding claim, formed during the bonding stage at a feed ratio of organosilicon monomer to oxidizing gas of from 2.5 to 10.
The invention of any preceding claim, formed during the buildup stage at a feed ratio of organosilicon monomer to oxidizing gas of from 0.1 to 0.05.
The invention of any preceding claim, in which the SiOx composite barrier coating or layer is formed by RF PECVD from an organosilicon monomer and oxidizing gas, at an initial RF power level from 20 to 4 W and a highest RF power level of from 300 W to 30 W.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 95% by the Article Deformation/Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 90% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 2 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an Si 2p chemical shift to lower binding energy (eV), compared to the binding energy of SiO4 bonding.
The invention of any preceding claim, in which
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 96% by the Article Deformation/Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 97% by the Article Deformation/Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 98% by the Article Deformation/Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 99% by the Article Deformation/Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is 100% by the Article Deformation/Tape Test Method.
The invention of any preceding claim, in which the Article Deformation/Tape Test Method is carried out using axial deformation.
The invention of any preceding claim, in which the Article Deformation/Tape Test Method is carried out using diametric deformation.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 91% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 92% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 93% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 94% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 95% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 96% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 97% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 98% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is at least 99% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the degree of retention of the composite barrier coating or layer on the substrate is 100% by the Coated Article Cross-Scratch Tape Test Method.
The invention of any preceding claim, in which the Coated Article Cross-Scratch Tape Test Method is carried out using an X scratch pattern.
The invention of any preceding claim, in which the Coated Article Cross-Scratch Tape Test Method is carried out using a rectangular scratch pattern.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 2 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 3 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 4 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 5 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 6 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 7 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 8 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 9 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 10 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 11 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 12 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 13 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 14 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 15 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 16 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 17 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 18 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 19 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having at least 20 mol. % O3—Si—C covalent bonding, as a proportion of the O3—Si—C covalent bonding plus SiO4 bonding.
The invention of any preceding claim, in which High Resolution X-ray Photoelectron Spectroscopy (XPS) shows the presence of an interface between the composite barrier coating or layer and the substrate having Si 2p peak broadening of at least 0.2 eV, compared to the binding energy of SiO4 bonding.
The invention of any preceding claim, in which the SiOx composite barrier coating or layer is formed by PECVD from an organosilicon monomer and oxidizing gas, in at least substrate ablation, SiOx bonding and SiOx buildup stages.
The invention of any preceding claim, in which the vessel has a rated volume between 0.2 and 50 ml.
The invention of any preceding claim, in which the vessel has a rated volume between 2 and 50 ml.
The invention of any preceding claim, in which the vessel has a rated volume between 2 and 20 ml.
The invention of any preceding claim, in which the vessel has a rated volume between 2 and 6 ml.
The invention of any preceding claim, in which the vessel has a rated volume between 3 and 5 ml.
The invention of any preceding claim, in which the vessel has a rated volume between 0.25 and 20 ml.
The invention of any preceding claim, in which the vessel has a rated volume between 0.5 and 5 ml.
The invention of any preceding claim, in which the vessel has a rated volume between 1 and 2 ml.
The invention of any preceding claim, in which the vessel has a fill volume between 0.3 and 75 ml.
The invention of any preceding claim, in which the vessel has a fill volume between 3 and 75 ml.
The invention of any preceding claim, in which the vessel has a fill volume between 3 and 30 ml.
The invention of any preceding claim, in which the vessel has a fill volume between 4 and 9 ml.
The invention of any preceding claim, in which the vessel has a fill volume between 4 and 8 ml.
The invention of any preceding claim, in which the vessel has a fill volume between 0.4 and 35 ml.
The invention of any preceding claim, in which the vessel has a fill volume between 0.8 and 9 ml.
The invention of any preceding claim, in which the vessel has a fill volume between 1.7 and 3.5 ml.
The invention of any preceding claim, in which the vessel is a vial.
The invention of any preceding claim, in which the vessel is a syringe.
The invention of any preceding claim, in which the vessel is a prefilled syringe.
The invention of any preceding claim, in which the vessel is a cartridge.
The invention of any preceding claim, in which the vessel is a sample tube.
The invention of any preceding claim, in which the vessel is an evacuated blood sample tube.
The invention of any preceding claim, in which the power density at the initial RF power level is from 3 to 1 W/mL.
The invention of any preceding claim, in which the power density at the highest RF power level is from 60 to 4 W/mL.
The invention of any preceding claim, in which the organosilicon monomer is an organosiloxane having from 2 to 6 silicon atoms per molecule.
The invention of any preceding claim, in which the organosilicon monomer is hexamethyldisiloxane.
The invention of any preceding claim, in which the organosilicon monomer is an organosiloxazane having from 2 to 6 silicon atoms per molecule.
The invention of any preceding claim, in which the organosilicon monomer is hexamethyldisiloxazane.
The invention of any preceding claim, wherein the SiOx composite barrier coating or layer is formed by PECVD from a gas feed comprising an organosilicon monomer, an oxidizing gas, and a carrier gas.
The invention of any preceding claim, in which the SiOx is formed from an organosilicon monomer and an oxidizing gas.
The invention of any preceding claim, in which the composite barrier coating or layer is applied by PECVD of a precursor feed comprising an organosiloxane, an organosilane, or an organosilazane.
The invention of any preceding claim, in which the composite barrier coating or layer is applied by PECVD of a precursor feed comprising a linear or branched siloxane having from 1 to 5 silicon atoms, a monocyclic siloxane, a polycyclic siloxane, a polysilsesquioxane, a monocyclic silazane, a polycyclic silazane, a polysilsesquiazane, a silatrane, a silquasilatrane, a silproatrane, an azasilatrane, an azasilquasiatrane, an azasilproatrane, or a combination of any two or more of these precursors.
The invention of any preceding claim, in which in which the composite barrier coating or layer is applied by PECVD of a precursor feed comprising a monocyclic siloxane, a polycyclic siloxane, a polysilsesquioxane, a silatrane, a silquasilatrane, a silproatrane, or a combination of any two or more of these precursors.
The invention of any preceding claim, in which the composite barrier coating or layer is applied by PECVD of a precursor feed comprising a monocyclic siloxane.
The invention of any preceding claim, in which the composite barrier coating or layer is applied by PECVD of a precursor feed comprising octamethylcyclotetrasiloxane (OMCTS).
The invention of any preceding claim, in which the composite barrier coating or layer is applied by PECVD of a precursor feed consisting essentially of octamethylcyclotetrasiloxane (OMCTS).
The invention of any preceding claim, in which the composite barrier coating or layer is applied by PECVD of a precursor feed comprising a monocyclic silazane, a polycyclic silazane, a polysilsesquiazane, an azasilatrane, an azasilquasiatrane, an azasilproatrane, or a combination of any two or more of these precursors.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises:
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises a polyolefin.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of a polyolefin.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises a cyclic olefin polymer.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of a cyclic olefin polymer.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises a cyclic olefin copolymer.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of a cyclic olefin copolymer.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises polypropylene.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of polypropylene.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises a polyester.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of a polyester.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises polyethylene terephthalate.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of polyethylene terephthalate.
The invention of any preceding claim, in which the vessel comprises a syringe barrel.
The invention of any preceding claim, in which the vessel comprises a vial.
The invention of any preceding claim, in which the vessel comprises a blister package.
The invention of any preceding claim, further comprising a fluid contained in the lumen of the vessel, in which the fluid composition has a pH between 5 and 6.
The invention of any preceding claim, further comprising a fluid contained in the lumen of the vessel, in which the fluid composition has a pH between 6 and 7.
The invention of any preceding claim, further comprising a fluid contained in the lumen of the vessel, in which the fluid composition has a pH between 7 and 8.
The invention of any preceding claim, further comprising a fluid contained in the lumen of the vessel, in which the fluid composition has a pH between 8 and 9.
The invention of any preceding claim, further comprising a fluid contained in the lumen of the vessel, in which the fluid composition has a pH between 6.5 and 7.5.
The invention of any preceding claim, further comprising a fluid contained in the lumen of the vessel, in which the fluid composition has a pH between 7.5 and 8.5.
The invention of any preceding claim, further comprising a fluid contained in the lumen of the vessel, in which the fluid composition has a pH between 8.5 and 9.
The invention of any preceding claim, further comprising a fluid contained in the lumen of the vessel, in which the fluid composition is a liquid at 20° C. and 760 mm Hg. atmospheric pressure.
The invention of any preceding claim, further comprising a fluid contained in the lumen of the vessel, in which the fluid composition is an aqueous liquid.
The invention of any preceding claim, in which the composite barrier coating or layer is from 4 nm to 500 nm thick.
The invention of any preceding claim, in which the composite barrier coating or layer is from 7 nm to 400 nm thick.
The invention of any preceding claim, in which the composite barrier coating or layer is from 10 nm to 300 nm thick.
The invention of any preceding claim, in which the composite barrier coating or layer is from 20 nm to 200 nm thick.
The invention of any preceding claim, in which the composite barrier coating or layer is from 30 nm to 100 nm thick.
The invention of any preceding claims 165 to 165167, in which the carrier gas comprises argon.
The invention of any preceding claims 165 to 165168, in which the precursor feed comprises:
The invention of any preceding claims 165 to 165169, in which the precursor feed comprises:
The invention of any preceding claims 165 to 165170, in which the pH protective coating or layer as applied is between 10 and 1000 nm thick.
The invention of any preceding claim, in which the invention is a syringe.
The invention of any preceding claim, in which the invention is a syringe comprising a syringe barrel.
The invention of any preceding claim, in which the invention is a syringe comprising a plunger.
The invention of any preceding claim, in which the invention is a syringe comprising a syringe barrel and a plunger.
The invention of any preceding claim, in which the invention is a syringe comprising a syringe barrel and a plunger and the wall defines at least a portion of the syringe barrel.
The invention of any preceding claim, in which the invention is a syringe comprising a syringe barrel and a plunger, the wall defines at least a portion of the syringe barrel, and the relatively sliding part comprises the syringe plunger.
The invention of any preceding claim, in which the calculated shelf life (total Si/Si dissolution rate) is more than 1 year.
The invention of any preceding claim, in which the calculated shelf life (total Si/Si dissolution rate) is less than 4 years.
The invention of any preceding claim, in which the calculated shelf life (total Si/Si dissolution rate) is less than 5 years.
SiNxCy s formula is from about 0.5 to 2.4, and y is from about 0.6 to about 3.
A composite material comprising:
The invention of any preceding claim, in which x for the pH protective layer is between 0.5 and 1.5 and y is between 0.9 and 2.
The invention of any preceding claims 1021 to 325, in which the Ra surface roughness value of the pH protective coating or layer, measured by atomic force microscopy, is from about 4 to about 6, optionally from about 4.6 to about 5.8.
The invention of any preceding claims 1021 to 326, in which the R max surface roughness value of the pH protective coating or layer, measured by atomic force microscopy, is from about 70 to about 160, optionally from about 84 to about 142, optionally from about 90 to about 130.
The invention of any preceding claim, in which the lumen contains a fluid composition comprising a member selected from the group consisting of:
1314-1400. (canceled)
A filled package comprising:
(canceled)
An article comprising:
A vessel comprising:
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises:
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises a polyolefin.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of a polyolefin.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises a cyclic olefin polymer.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of a cyclic olefin polymer.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises a cyclic olefin copolymer.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of a cyclic olefin copolymer.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises polypropylene.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of polypropylene.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises a polyester.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of a polyester.
The invention of any preceding claim, in which at least a portion of the wall of the vessel comprises polyethylene terephthalate.
The invention of any preceding claim, in which at least a portion of the wall of the vessel consists essentially of polyethylene terephthalate.
The invention of any preceding claim, in which the vessel comprises a syringe barrel.
The invention of any preceding claim, in which the fluid composition has a pH between 6.5 and 7.5.
The invention of any preceding claim, in which the fluid composition has a pH between 7.5 and 8.5.
The invention of any preceding claim, in which the fluid composition has a pH between 8.5 and 9.
The invention of any preceding claim, in which the fluid composition is a liquid at 20° C. and 760 mm Hg. atmospheric pressure.
The invention of any preceding claim, in which the fluid composition is an aqueous liquid.
The invention of any preceding claim, in which the pH protective coating or layer comprises SiOxCy.
The invention of any preceding claim, in which the pH protective coating or layer consists essentially of SiOxCy.
The invention of any preceding claim, in which the pH protective coating or layer comprises SiNxCy.
The invention of any preceding claim, in which the pH protective coating or layer consists essentially of SiNxCy.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD of a precursor feed comprising an acyclic siloxane, a monocyclic siloxane, a polycyclic siloxane, a polysilsesquioxane, a monocyclic silazane, a polycyclic silazane, a polysilsesquiazane, a silatrane, a silquasilatrane, a silproatrane, an azasilatrane, an azasilquasiatrane, an azasilproatrane, or a combination of any two or more of these precursors.
The invention of any preceding claim, in which in which the pH protective coating or layer is applied by PECVD of a precursor feed comprising an acyclic siloxane, a monocyclic siloxane, a polycyclic siloxane, a polysilsesquioxane, a silatrane, a silquasilatrane, a silproatrane, or a combination of any two or more of these precursors.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD of a precursor feed comprising a monocyclic siloxane.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD of a precursor feed comprising octamethylcyclotetrasiloxane (OMCTS).
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD of a precursor feed consisting essentially of octamethylcyclotetrasiloxane (OMCTS).
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD of a precursor feed comprising a monocyclic silazane, a polycyclic silazane, a polysilsesquiazane, an azasilatrane, an azasilquasiatrane, an azasilproatrane, or a combination of any two or more of these precursors.
1444A. The invention of any preceding claim 1439-1444, in which the precursor feed further comprises oxygen.
1444B. The invention of any preceding claim 1439-1444A, in which the precursor feed further comprises a carrier gas.
1444C. The invention of claim 44B, in which the carrier gas comprises argon.
1444D. The invention of any preceding claim 1439-1444C, in which the precursor feed comprises:
1444E. The invention of any preceding claim 1439-1444D, in which the precursor feed comprises:
The invention of any preceding claim, in which the pH protective coating or layer as applied is between 10 and 1000 nm thick.
The invention of any preceding claim, in which the pH protective coating or layer as applied is between 50 and 800 nm thick.
The invention of any preceding claim, in which the pH protective coating or layer as applied is between 100 and 700 nm thick.
The invention of any preceding claim, in which the pH protective coating or layer as applied is between 300 and 600 nm thick.
1464A. The invention of any preceding claim 1401, 1402, or 1404-1462, having a shelf life, after the invention is assembled, of at least three years.
1464B. The invention of any preceding claim 1401, 1402, or 1404-1462, having a shelf life, after the invention is assembled, of at least four years.
1464C. The invention of any preceding claim 1401, 1402, or 1404-1462, having a shelf life, after the invention is assembled, of at least five years.
1464D. The invention of any preceding claim 1401, 1402, or 1404-1462, having a shelf life, after the invention is assembled, of at least six years.
1464E. The invention of any preceding claim 1401, 1402, or 1404-1462, having a shelf life, after the invention is assembled, of at least seven years.
1464F. The invention of any preceding claim 1401, 1402, or 1404-1462, having a shelf life, after the invention is assembled, of at least eight years.
1464G. The invention of any preceding claim 1401, 1402, or 1404-1462, having a shelf life, after the invention is assembled, of at least nine years.
1464H. The invention of any preceding claim 1463-1464G, having a shelf life, after the invention is assembled, of at most ten years.
The invention of any preceding claim, in which the fluid composition removes the pH protective coating or layer at a rate of 1 nm or less of pH protective coating or layer thickness per 44 hours of contact with the fluid composition.
The invention of any preceding claim, in which the fluid composition removes the pH protective coating or layer at a rate of 1 nm or less of pH protective coating or layer thickness per 88 hours of contact with the fluid composition.
The invention of any preceding claim, in which the fluid composition removes the pH protective coating or layer at a rate of 1 nm or less of pH protective coating or layer thickness per 175 hours of contact with the fluid composition.
The invention of any preceding claim, in which the fluid composition removes the pH protective coating or layer at a rate of 1 nm or less of pH protective coating or layer thickness per 250 hours of contact with the fluid composition.
The invention of any preceding claim, in which the fluid composition removes the pH protective coating or layer at a rate of 1 nm or less of pH protective coating or layer thickness per 350 hours of contact with the fluid composition.
The invention of any preceding claim, in which the pH protective coating or layer is effective to provide a lower frictional resistance than the uncoated interior surface.
The invention of any preceding claim, in which the pH protective coating or layer is effective to reduce the frictional resistance between a portion of the wall contacted by the fluid composition and a relatively sliding part after the invention is assembled.
The invention of any preceding claim, in which the pH protective coating or layer is effective to reduce the frictional resistance between the wall and a relatively sliding part at least two years after the invention is assembled.
The invention of any preceding claim, further comprising
The invention of any preceding claim, in which an FTIR absorbance spectrum of the pH protective coating or layer has a ratio greater than 0.75 between:
The invention of any preceding claim, in which the pH protective coating or layer has a non-oily appearance.
The invention of any preceding claim, in which the silicon dissolution rate by a 50 mM potassium phosphate buffer diluted in water for injection, adjusted to pH 8 with concentrated nitric acid, and containing 0.2 wt. % polysorbate-80 surfactant from the vessel is less than 170 ppb/day.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of more than 22,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of more than 30,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of more than 40,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of more than 50,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of more than 60,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of more than 62,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of more than 70,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of more than 80,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of less than 100,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
The invention of any preceding claim, in which the pH protective coating or layer is applied by PECVD at a power level per of less than 90,000 kJ/kg of mass of polymerizing gases in the PECVD reaction chamber.
1538A. The invention of any preceding claim 1401-1537, in which the pH protective coating or layer is applied by PECVD at a power level per of from 0.1 to 400 W.
The invention of any preceding claim, in which the ratio of the electrode power to the plasma volume is from 1 W/ml to 100 W/ml.
1549H. The invention of any preceding claim, further comprising a lubricity coating or layer between the lumen and the pH protective coating or layer, the lubricity coating comprising SiOxCy or SiNxCy wherein x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3, the lubricity coating or layer being effective to increase the lubricity of the coating set above that of a coating set having a pH protective coating as the layer confronting the lumen.
1549A. The invention of any preceding claim, in which the pH protective coating or layer has an RMS surface roughness value (measured by AFM) of from about 5 to about 9.
1549B. The invention of any preceding claim, in which the pH protective coating or layer has an RMS surface roughness value (measured by AFM) of from about 6 to about 8.
1549C. The invention of any preceding claim 1401-1549, in which the pH protective coating or layer has an RMS surface roughness value (measured by AFM) of from about 4 to about 6.
1549D. The invention of any preceding claim 1401-1549, in which the pH protective coating or layer has an RMS surface roughness value (measured by AFM) of from about 4.6 to about 5.8.
1549E. The invention of any preceding claim, in which the pH protective coating or layer has an Rmax surface roughness value of the pH protective coating or layer, measured by AFM, from about 70 to about 160.
1549F. The invention of any preceding claim, in which the pH protective coating or layer has an Rmax surface roughness value of the pH protective coating or layer, measured by AFM, from about 84 to about 142.
1549G. The invention of any preceding claim, in which the pH protective coating or layer has an Rmax surface roughness value of the pH protective coating or layer, measured by AFM, from about 90 to about 130.
The invention of any preceding claim, comprising a syringe barrel coated on its interior wall with a pH protective coating or layer, the invention further comprising a plunger positioned for sliding in the barrel and a lubricity coating or layer on at least a portion of the plunger.
The invention of any preceding claim, wherein the pH protective coating or layer shows an O-Parameter measured with attenuated total reflection (ATR) of less than 0.4, measured as:
The invention of any preceding claim, wherein the pH protective coating or layer shows an N-Parameter measured with attenuated total reflection (ATR) of less than 0.7, measured as:
A composite material comprising:
The invention of any preceding claim, in which x is between 0.5 and 1.5 and y is between 0.9 and 2.
The invention of any preceding claim, in which x is between 0.7 and 1.3 and y is between 0.9 and 2.
The invention of any preceding claim, in which x is between 0.8 and 1.2 and y is between 0.9 and 1.5.
The invention of any preceding claim, in which x is between 0.9 and 1.2 and y is between 0.9 and 1.4.
The invention of any preceding claim, in which x is between 0.92 and 1.07 and y is between 1.16 and 1.33.
The invention of any preceding claim, in which the RMS surface roughness value of the pH protective coating or layer, measured by atomic force microscopy, is from about 5 to about 9, optionally from about 6 to about 8, optionally from about 6.4 to about 7.8.
The invention of any preceding claim, in which the Ra surface roughness value of the pH protective coating or layer, measured by atomic force microscopy, is from about 4 to about 6, optionally from about 4.6 to about 5.8.
The invention of any preceding claim, in which the Rmax surface roughness value of the pH protective coating or layer, measured by atomic force microscopy, is from about 70 to about 160, optionally from about 84 to about 142, optionally from about 90 to about 130.
1586-1634. (canceled)
The invention of any preceding claim, in which the tie coating or layer comprises SiOxCy.
The invention of any preceding claim, in which the tie coating or layer consists essentially of SiOxCy.
The invention of any preceding claim, in which the tie coating or layer comprises SiNxCy.
The invention of any preceding claim, in which the tie coating or layer consists essentially of SiNxCy.
The invention of any preceding claim, in which the tie coating or layer is applied by PECVD of a precursor feed comprising an acyclic siloxane, a monocyclic siloxane, a polycyclic siloxane, a polysilsesquioxane, a monocyclic silazane, a polycyclic silazane, a polysilsesquiazane, a silatrane, a silquasilatrane, a silproatrane, an azasilatrane, an azasilquasiatrane, an azasilproatrane, or a combination of any two or more of these precursors.
The invention of any preceding claim, in which in which the tie coating or layer is applied by PECVD of a precursor feed comprising an acyclic siloxane, a monocyclic siloxane, a polycyclic siloxane, a polysilsesquioxane, a silatrane, a silquasilatrane, a silproatrane, or a combination of any two or more of these precursors.
The invention of any preceding claim, in which the tie coating or layer is applied by PECVD of a precursor feed comprising a monocyclic siloxane.
The invention of any preceding claim, in which the tie coating or layer is applied by PECVD of a precursor feed comprising octamethylcyclotetrasiloxane (OMCTS).
1642a. The invention of any preceding claim, in which the tie coating or layer is applied by PECVD of a precursor feed comprising tetramethyldisiloxane (TMDSO).
1642b. The invention of any preceding claim, in which the tie coating or layer is applied by PECVD of a precursor feed comprising hexamethyldisiloxane (HMDSO).
The invention of any preceding claim, in which the tie coating or layer is applied by PECVD of a precursor feed consisting essentially of octamethylcyclotetrasiloxane (OMCTS).
1643a. The invention of any preceding claim, in which the tie coating or layer is applied by PECVD of a precursor feed consisting essentially of tetramethyldisiloxane (TMDSO).
1643b. The invention of any preceding claim, in which the tie coating or layer is applied by PECVD of a precursor feed consisting essentially of hexamethyldisiloxane (HMDSO).
The invention of any preceding claim, in which the tie coating or layer is applied by PECVD of a precursor feed comprising a acyclic silazane, a monocyclic silazane, a polycyclic silazane, a polysilsesquiazane, an azasilatrane, an azasilquasiatrane, an azasilproatrane, or a combination of any two or more of these precursors.
1644A. The invention of any preceding claim 1639-1644, in which the precursor feed for the tie coating or layer further comprises oxygen.
1644B. The invention of any preceding claim 1639-1644A, in which the precursor feed for the tie coating or layer further comprises a carrier gas.
1644C. The invention of any preceding claim 1644B, in which the carrier gas for the tie coating or layer comprises argon.
1644D. The invention of any preceding claim 1639-1644C, in which the precursor feed for the tie coating or layer comprises:
1644E. The invention of any preceding claim 1639-1644D, in which:
1644F. The invention of any preceding claim 1639-1644D, in which:
The invention of any preceding claim, in which the tie coating or layer is on average between 5 and 200 nm thick.
The invention of any preceding claim, in which the tie coating or layer on average is between 5 and 100 nm thick.
The invention of any preceding claim, in which the tie coating or layer on average is between 10 and 100 nm thick.
The invention of any preceding claim, in which the tie coating or layer on average is between 10 and 50 nm thick.
The invention of any preceding claim 1401 or 1403-1659, in which the tie coating or layer is at least coextensive with the barrier coating or layer.
The invention of any preceding claim in which the barrier coating or layer on average is between 10 and 200 nm thick.
The invention of any preceding claim in which the barrier coating or layer on average is between 10 and 100 nm thick.
The invention of any preceding claim in which the pH protective coating or layer on average is between 50 and 400 nm thick.
The invention of any preceding claim in which the pH protective coating or layer on average is between 50 and 250 nm thick.
The invention of any preceding claim, in which the range of thickness of the tie coating or layer is between 5 and 200 nm thick.
The invention of any preceding claim, in which the range of thickness of the tie coating or layer is between 5 and 100 nm thick.
The invention of any preceding claim, in which the range of thickness of the tie coating or layer is between 10 and 100 nm thick.
The invention of any preceding claim, in which the range of thickness of the tie coating or layer is between 10 and 50 nm thick.
The invention of any preceding claim in which the range of thickness of the barrier coating or layer is between 10 and 200 nm thick.
The invention of any preceding claim in which the range of thickness of the barrier coating or layer is between 10 and 100 nm thick.
The invention of any preceding claim in which the range of thickness of the pH protective coating or layer is between 50 and 400 nm thick.
The invention of any preceding claim in which the range of thickness of the pH protective coating or layer is between 50 and 250 nm thick.
The invention of any preceding claim, in which the fluid comprises a member selected from the group consisting of:
Dependencies are inferred from the claim text.