US 2021/0330867 A1 · TEMPERATURE SENSITIVE COMPOSITION FOR TISSUE ADHESION PREVENTION AND APPLICATION THEREOF

Abstract

The present invention relates to a composition comprising an amino acid-modified polymer, a carboxypolysaccharide, and may further include a metal ion for anti-adhesion and vector application. More specifically, the invention relates to a thermosensitive composition having enhanced mechanical and improved water-erosion resistant properties for efficiently preventing tissue adhesions and can serve as a vector with bio-compatible, bio-degradable/absorbable, and in-vivo sustainable properties.

Claims15

Dependent claims

A composition comprising a polymer, and a carboxypolysaccharide, wherein the polymer having any one structure of the following formula (I):

or a combination thereof,
wherein:
POLY is a triblock copolymer of poly(ethylene oxide)(PEO)-poly(propylene oxide)(PPO)-poly(ethylene oxide)(PEO);
m and n are independently from each other 0 or 1, wherein m and n cannot be 0 simultaneously;
and
AA is an amino acid residue, where its amino group directly binds to the chain-end of the POLY to form carbamate (O—C(═O)—NH) linkage.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/239,092Filed 23 Apr 2021

Priority

24 Apr 2020

Published

28 Oct 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

C08G 65/33306
Containing amino group: acyclic
C08G 81/00
Macromolecular compounds obtained by interreacting polymers in the absence of monomers
A61K 31/337
Having oxygen as the only ring hetero atom, e.g. fungichromin: having four-membered rings, e.g. taxol
A61K 47/34
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: macromolecular compounds obtained otherwise than by reactions only…

Temperature sensitive composition for tissue adhesion prevention and application thereof

Life of this patent

Temperature sensitive composition for tissue adhesion prevention and application thereof

Life of this patent

Abstract

Claims15