Nitric oxide producing collagen/orc dressing
AssigneeSystagenix Wound Management, Limited
InventorsAlexander WAITE, Carrina WARD
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Abstract
The present disclosure provides wound dressing compositions that stimulate nitric oxide production in a wound upon application. The wound dressing composition includes a first layer comprising collagen and an oxidized cellulose and a second layer comprising a nitrite source. Also disclosed herein are kits comprising the wound dressing compositions of the present technology.
Claims50
A wound dressing composition comprising a first layer and a second layer, wherein the first layer comprises a collagen and an oxidized cellulose, and wherein the second layer comprises a nitrite source, optionally wherein the collagen is selected from the group consisting of a mammalian collagen, a marine collagen, a porcine collagen, a bovine collagen, an ovine collagen, an equine collagen, a mammalian recombinant collagen, a human recombinant collagen and any combination thereof.
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A method for protecting a wound from infection or treating a wound in a subject in need thereof, comprising administering to the wound a wound dressing composition comprising a first layer and a second layer, wherein the first layer comprises an effective amount of a collagen and an oxidized cellulose, and wherein the second layer comprises an effective amount of a nitrite source.
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A method for making a wound dressing comprising:
- a. providing a first layer comprising an effective amount of a collagen and an oxidized cellulose;
- b. providing a second layer comprising an effective amount of a nitrite source;
- and
- c. combining the first layer and the second layer to form the wound dressing.
Dependencies are inferred from the claim text.