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US 2021/0330823 A1Published application
Methods for Cell Labeling and Medical Imaging
AssigneeMayo Foundation for Medical Education and Research
InventorsAditya Bansal, Timothy R. DeGrado, Mukesh K. Pandey
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Abstract
Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.
Claims20
A method for preparing a labeling agent, the method comprising:
- (a) providing a compound including a chelating moiety and a conjugation moiety;
- and
- (b) mixing the compound with a radionuclide to create the labeling agent before reacting the compound with an additional moiety,
- wherein the chelating moiety includes a hydroxamic acid group and the conjugation moiety includes an isothiocyanate group.
1 more element
Dependencies are inferred from the claim text.