Lipid-coated particles for treating viral infections
AssigneesNational Technology & Engineering Solutions of Sandia, LLC, UNM Rainforest Innovations
InventorsOscar Negrete, C. Jeffrey Brinker, Torri Rinker, Annette Estelle LaBauve
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Abstract
The present invention relates to lipid-coated particles for treating viral infections, including viral encephalitis infections. In particular, an antiviral compound can be disposed within the lipid-coated particle, thereby providing an antiviral carrier. Methods of making and using such carriers are described herein.
Claims20
A method of reducing brain viral load within a subject, the method comprising:
- administering an effective amount of a lipid-coated particle to the subject, wherein the lipid-coated particle comprises a porous core and an antiviral compound disposed within at least one pore of the porous core.
A method of treating cancer within a subject, the method comprising:
- administering an effective amount of a lipid-coated particle to the subject, wherein the lipid-coated particle comprises a porous core and an anticancer compound disposed within at least one pore of the porous core.
A method of increasing a stability and/or a solubility of an antiviral compound within an aqueous solution, the method comprising:
- incubating the antiviral compound with a core comprising a plurality of pores, thereby providing a loaded core;
- and
- coating the loaded core with a lipid layer, thereby provided a lipid-coated particle,
- wherein the stability and/or the solubility of the lipid-coated particle within the aqueous solution is greater than the stability and/or the solubility of the antiviral compound within the aqueous solution.
Dependencies are inferred from the claim text.