Small polymeric carriers for delivery of agents
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsJingjing Sun, Song Li
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Abstract
A polymer includes a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one group including a plurality of hydroxyl groups, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer.
Claims93
A polymer, comprising:
- a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one group comprising a plurality of hydroxyl groups, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer, wherein at least one of the first plurality of pendant groups or the second plurality of pendant groups is attached to the hydrophobic polymer backbone via a linking moiety comprising at least one group which is interactive via π-π stacking.
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The polymer of claim 20 wherein the nucleoside is selected from the group consisting of a gemcitabine, azacytidine, cytarabine, or a biologically active derivative thereof.
The polymer of claim 21 wherein the therapeutic agent is a nucleoside.
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A formulation, comprising:
- a plurality of polymers comprising a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one group comprising a plurality of hydroxyl groups, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer, and at least a first compound which is a hydrophobic therapeutic compound or a hydrophobic diagnostic compound, wherein at least one of the first plurality of pendant groups or the second plurality of pendant groups is attached to the hydrophobic polymer backbone via a linking moiety comprising at least one group which is interactive via π-π stacking, and wherein the plurality of polymers self-assemble into nanocarriers in an aqueous environment into which the first compound is loaded.
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The formulation of claim 70 wherein the nucleoside is selected from the group consisting of a gemcitabine, azacytidine, cytarabine or a biologically active derivative thereof.
The formulation of claim 71 wherein the therapeutic agent is a nucleoside.
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A method of formulating a composition for delivery of a first compound, which is a hydrophobic therapeutic compound or a hydrophobic diagnostic compound, comprising:
- mixing a plurality of polymers comprising a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one group including a plurality of hydroxyl groups, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer with a plurality of the first compounds, wherein at least one of the first plurality of pendant groups or the second plurality of pendant groups is attached to the hydrophobic polymer backbone via a linking moiety comprising at least one group which is interactive via π-π stacking, and wherein the plurality of polymers self-assemble into nanocarriers in an aqueous environment into which the first compound is loaded.
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Dependencies are inferred from the claim text.