Protein-antiviral compound conjugates
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsAlina BAUM, Thomas NITTOLI
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Abstract
Provided herein are compounds, compositions, and methods for the treatment of diseases and disorders associated with influenza, including VX-787 and derivatives thereof, baloxavir and derivatives thereof, and baloxavir marboxil and derivatives thereof, and protein (e.g., antibody) drug conjugates thereof.
Claims33
An antibody-drug conjugate comprising an anti-influenza antibody or antigen-binding fragment thereof conjugated to an antiviral compound.
A compound having the following structure
- wherein
- L is a linker;
- BA is a binding agent;
- and
- k is an integer from one to thirty.
16-24. (canceled)
(canceled)
29-34. (canceled)
36-57. (canceled)
A linker-antiviral compound having the following structure
- or a pharmaceutically acceptable salt thereof, wherein
- L is a linker;
- and
- RG is a reactive moiety.
64-72. (canceled)
Dependencies are inferred from the claim text.