Compositions comprising tri- and penta-block synthetic copolypeptide hydrogels

A composition comprising:

• i) a first copolypeptide comprising Substructure I, and a second copolypeptide comprising Substructure II, and water, wherein
• Substructure I is depicted as follows:
• -A1n1-B1m1-A1n1- Substructure I;
• Substructure II is depicted as follows:
• —X1n2—Y1m2—X1n2— Substructure II;
• each instance of A1 is an amino acid residue independently selected from a non-ionic hydrophilic amino acid, sarcosine, glycine, and alanine;
• in at least 20% of the instances of B1, B1 is an amino acid residue independently selected from an anionic hydrophilic amino acid or a salt thereof;
• each instance of X1 is an amino acid residue independently selected from a non-ionic hydrophilic amino acid, sarcosine, glycine, and alanine;
• in at least 20% of the instances of Y1, Y1 is an amino acid residue independently selected from a cationic hydrophilic amino acid or a salt thereof;
• each n1 and n2 is independently about 25 to about 600;
• m1 and m2 are independently about 15 to about 600;
• at least 75 mol % of the B1 amino acid residues are (D)-amino acid residues or at least 75 mol % of the B1 amino acid residues are (L)-amino acid residues;
• at least 75 mol % of the Y1 amino acid residues are (D)-amino acid residues or at least 75 mol % of the Y1 amino acid residues are (L)-amino acid residues;
• and
• the first copolypeptide and the second copolypeptide are not covalently linked;
• or
• ii) Substructure III, and a second copolypeptide comprising Substructure IV, and water, wherein Substructure III is depicted as follows:
• -A1n1-B1m1-A1n3-B1m1-A1n1- Substructure III:
• Substructure IV is depicted as follows:
• —X1n2—Y1m2—X1n4—Y1m2—X1n2— Substructure IV;
• each instance of A1 is an amino acid residue independently selected from a non-ionic, hydrophilic amino acid, sarcosine, glycine, and alanine;
• in at least 20% of the instances of B1, B1 is an amino acid residue independently selected from an anionic hydrophilic amino acid or a salt thereof;
• each instance of X1 is an amino acid residue independently selected from a non-ionic hydrophilic amino acid, sarcosine, glycine, and alanine;
• in at least 20% of the instances of Y1, Y1 is an amino acid residue independently selected from a cationic hydrophilic amino acid or a salt thereof;
• each n1, n2, n3, and n4 is independently about 25 to about 600;
• each m1 and m2 is independently about 15 to about 600;
• at least 75 mol % of the B1 amino acid residues are (D)-amino acid residues or at least 75 mol % of the B1 amino acid residues are (L)-amino acid residues;
• at least 75 mol % of the Y1 amino acid residues are (D)-amino acid residues or at least 75 mol % of the Y1 amino acid residues are (L)-amino acid residues;
• and
• the first copolypeptide and the second copolypeptide are not covalently linked.