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US 2021/0330793 A1Published application
Methods and compositions for self-regulated release of active pharmaceutical ingredient
AssigneeAcura Pharmaceuticals, Inc.
InventorsAlbert W. BRZECZKO, R. Gary HOLLENBECK
Life of this patent
Estimating the term…
Abstract
An abuse deterrent pharmaceutical composition including a pharmaceutically active ingredient; an acid soluble ingredient; and a buffering ingredient; wherein the acid soluble ingredient and the buffering ingredient retard release of the active pharmaceutical ingredient when the composition is ingested in excess of an intended dosage.
Claims20
-9. (canceled)
An abuse deterrent pharmaceutical composition comprising:
- a. a pharmaceutically active ingredient;
- b. an acid soluble ingredient;
- and
- c. a buffering ingredient;
- wherein the buffering ingredient is in an amount sufficient to retard release of the pharmaceutically active ingredient when the composition is ingested in excess of a dosage appropriate to provide a therapeutic effect.
2 more elements
An abuse deterrent pharmaceutical composition comprising:
- a. a pharmaceutically active ingredient;
- b. an acid soluble ingredient;
- and
- c. a buffering ingredient;
- wherein the buffering ingredient is in an amount sufficient to suppress peak plasma concentration (Cmax) of the pharmaceutically active ingredient when the composition is ingested in excess of a dosage appropriate to provide a therapeutic effect.
2 more elements
An abuse deterrent pharmaceutical composition comprising:
- a. a pharmaceutically active ingredient;
- b. an acid soluble ingredient;
- and
- c. a buffering ingredient;
- wherein the buffering ingredient is in an amount sufficient to retard release of the pharmaceutically active ingredient at a pH exceeding about 4 but does not substantially retard release of the pharmaceutically active ingredient at a pH below about 4.
2 more elements
Dependencies are inferred from the claim text.