Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same
AssigneeThe Trustees of the University of Pennsylvania
InventorsDavid B. Weiner, Matthew Morrow
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Abstract
Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
Claims17
An immunogenic pharmaceutical composition comprising:
- an isolated nucleic acid molecule that encodes an immunogen,
- wherein the immunogen is a viral protein;
- and
- an isolated nucleic acid molecule that encodes IL-28 or functional fragments thereof.
An immunogenic pharmaceutical composition comprising an isolated nucleic acid molecule comprising a nucleotide sequence that encodes an immunogen;
- and a nucleotide sequence that encodes IL-28 or a functional fragment thereof,
- wherein the immunogen is a viral protein.
A recombinant vaccine comprising a nucleotide sequence that encodes an immunogen operably linked to regulatory elements, and a nucleotide sequence that encodes IL-28 or a functional fragment thereof,
- wherein the immunogen is a viral protein.
-18. (canceled)
Dependencies are inferred from the claim text.