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US 2021/0330781 A1Published application
Induce and enhance immune responses using recombinant replicon systems
AssigneeJanssen Pharmaceuticals, Inc.
InventorsKurt Iver KAMRUD, Nathaniel Stephen WANG, Parinaz ALIAHMAD, Jason L. DEHART
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Abstract
The present disclosure generally relates to the use of different self-amplifying RNA molecules to enhance immune responses, for example immune responses following prophylactic vaccination or therapeutic administration. Some embodiments relate to compositions and methods for inducing an immune response in a subject using prime-boost immunization regimens.
Claims2
A composition comprising:
- a priming composition comprising a first RNA replicon which encodes a first antigen;
- and
- a boosting composition comprising a second RNA replicon which encodes a second antigen wherein the first and second RNA replicons are different from each other.
A composition comprising:
- a first nucleic acid sequence encoding a first RNA replicon which encodes a first antigen;
- and
- a second nucleic acid sequence encoding a second RNA replicon which encodes a second antigen,
- wherein the first and second RNA replicons are different from each other,
- wherein the first replicon and/or the second replicon comprises at least one expression cassettes comprising a promoter operably linked to a coding sequence for a molecule of interest.
2 more elements
Dependencies are inferred from the claim text.