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AssigneeMerck Sharp & Dohme Corp.
InventorsJian He, John E. MacNair, William J. Smith, Michael A. Winters, Joseph G. Joyce, Chitrananda Abeygunawardana, Luwy Musey, Hari Pujar, Julie M. Skinner, Patrick McHugh
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The present invention provides immunogenic compositions having one or more polysaccharide-protein conjugates in which one or more polysaccharides from Streptococcus pneumoniae bacterial capsules are conjugated to a carrier protein in an aprotic solvent such as dimethylsulfoxide (DMSO). The present invention also provides methods for providing an enhanced immune response to a pneumococcal polysaccharide protein conjugate vaccine comprising administering to a human subject an immunogenic composition comprising polysaccharide-protein conjugates prepared in DMSO conditions.
An immunogenic composition comprising polysaccharide from S. pneumoniae serotype conjugated to a carrier protein, wherein the conjugation reaction whereby the polysaccharide is conjugated to the carrier protein is in an aprotic solvent.
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Dependencies are inferred from the claim text.