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US 2021/0330766 A1Published application
Albumin-Free Botulinum Toxin Formulations
AssigneeRevance Therapeutics, Inc.
InventorsStewart A. Thompson, Curtis L. Ruegg, Jacob M. Waugh
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Abstract
This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.
Claims18
A pharmaceutical composition comprising a liquid carrier, wherein the liquid carrier comprises a botulinum toxin,
- a non-ionic surfactant, one or more non-reducing sugars selected from non-reducing disaccharides and a non-reducing trisaccharides,
- a bulking agent, and a physiologically compatible buffer,
- wherein the concentration of the bulking agent is in the range of 1% to 10%, and
- wherein the concentration of the non-reducing sugar is in the range of 0.50 to 3.0% (w/v),
- wherein the liquid carrier is formulated such that upon vacuum drying or lyophilization an amorphous solid is formed.
2 more elements
Dependencies are inferred from the claim text.