Plasminogen treatment of conditions associated with pai-1 overexpression
AssigneePrometic Biotherapeutics, Inc.
InventorsLYNE GAGNON, BRIGITTE GROUIX, PIERRE LAURIN
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Abstract
The present invention concerns the use of plasminogen, a variant thereof, or an analog thereof having a plasminogen activity, for the prevention or treatment of a condition or a disease that is characterized with an increased PAI-1 level. The conditions and diseases that are characterized with an increased PAI-1 level, are regrouped within two categories: the diseases associated with an impaired vascular or tissue remodeling capacity, and the metabolic and hormonal disorders associated with an increased PAI-1 level.
Claims13
A method for preventing, slowing progression of, or treating, a disease or a condition in a subject, whererein said disease or condition is associated with an overexpression of PAI-1, wherein the method comprises the administration of plasminogen, a variant thereof or an analog thereof to the subject.
12-15. (canceled)
A method for down-regulating a PAI-1 overexpression in an injured tissue of a subject, wherein said method comprises the administration of plasminogen, a variant thereof or an analog thereof to the subject.
Dependencies are inferred from the claim text.