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US 2021/0330759 A1Published application
Methods and compositions for treating cytokine storm, ards, and acute lung injury using beta-glucocerebrosidase
OwnerXiaoxia Li, Junjie Zhao +1inventors
InventorsXiaoxia Li, Junjie Zhao, Quanri Zhang
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Abstract
The present invention relates to methods and compositions for treating a subject with a condition selected from: i) an on-going cytokine storm, ii) acute respiratory distress syndrome (ARDS), and/or iii) acute lung injury (ALI), using a composition comprising β-glucocerebrosidase, or a vector encoding β-glucocerebrosidase. In certain embodiments, the condition is caused by COVID-19 virus infection or other viral infection.
Claims18
A method of treating a subject comprising:
- administering or providing a composition to a subject,
- wherein said composition comprises β-glucocerebrosidase, or a vector encoding β-glucocerebrosidase, and
- wherein said subject a condition selected from:
- i) an on-going cytokine storm, ii) acute respiratory distress syndrome (ARDS), and/or iii) acute lung injury (ALI).
1 more element
An in vitro composition comprising:
- a) β-glucocerebrosidase, or a vector encoding β-glucocerebrosidase, and
- b) a respiratory virus.
A system or kit comprising:
- a) an airway administration device, and
- b) a composition comprising β-glucocerebrosidase, or a vector encoding β-glucocerebrosidase.
Dependencies are inferred from the claim text.