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US 2021/0330756 A1Published application
Acetylation of Miro1
AssigneeUniversity of South Carolina
InventorsJeffery L. Twiss, Amar N. Kar
Life of this patent
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Abstract
Deacetylation of rat Miro1 on Lysine 105 attenuates axon growth on non-permissive substrates by making mitochondria more sensitive to Ca levels, depolarizing mitochondrial membranes and blocking mitochondrial transport; the current disclosure provides an antibody that specifically recognizes the lysine 105 acetylated and not the deacetylated Miro1 protein.
Claims18
A method for supporting axon growth comprising:
- sustaining mitochondrial transport and mitochondrial membrane potential in a presence of CNS axon growth inhibitors via administering acetyl-Miro1;
- and
- inhibiting histone deacetylase 6 (HDAC6).
A method for protecting axons from mitochondrial damage comprising:
- administering tubastatin (TubA) to axons;
- and
- wherein administration of TubA inhibits histone deacetylase 6 (HDAC6).
Dependencies are inferred from the claim text.