Insulins Compatible with New Generation Implantable Pumps

A closed device for introducing preservative-free insulin into the intraperitoneal space, comprising:

• an insulin reservoir configured to store preservative-free insulin;
• a pump connected to the reservoir;
• an antimicrobial reservoir outlet filter connected to an outlet of the reservoir;
• wherein the device is configured to be disposed in the intraperitoneal space of a body, and to discharge, preservative-free insulin into a peritoneal space of the body.

A method of providing osmotic pressure at the tip of a catheter used to discharge insulin via a reservoir, pump and catheter into the intraperitoneal space, comprising:

• providing a semi-permeable membrane in the catheter;
• providing insulin in the reservoir so that it is hypertonic relative to tissue surrounding the catheter;
• and
• passing the hypertonic insulin through catheter walls comprising a semi permeable membrane material, such that water is driven into the catheter by osmosis so as to generate a defined osmotic pressure at the tip of the catheter, said osmotic pressure pi defined as π=MRT,
• wherein:
• M is the molar concentration of dissolved species (units of mol/L);
• R is the ideal gas constant (0.08206 L atm mol−1 K−1, or other values depending on the pressure units);
• and T is the temperature on the Kelvin scale.