Lactate-protected hypoglycemia to treat glycolysis dependent pathological conditions, in particular cancer

A method of treatment using the kit of clam 1, wherein the treatment comprises:

• a) optional pre-procedural fasting,
• b) optionally administering the metformin, in particular one day before the start of the administration of the lactic acid,
• c) subsequently administering the lactic acid or a combination of lactic acid and sodium lactate to increase the lactate concentration in the body of the human or animal to about 5 to 20 mmol/L,
• d) subsequently administering a loading dose of the insulin to lower the blood glucose level to about 0.5 to 2.5 mmol/L, accompanied by continuous administration of insulin to maintain the glucose level at 0.5 to 2.5 mmol/L to achieve a hypoglycemic state,
• e) maintaining the hypoglycemic state for 0.5 to 12 h, supported by “clamping”, and
• f) ceasing the administration of insulin and administration of glucose to restore the physiological glucose level in the human or animal body and ceasing the administration of lactic acid.