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US 2021/0330745 A1Published application
Modulating renal lymphatics to regulate blood pressure
AssigneeThe Texas A&M University System
InventorsBrett Mitchell, Dongin Kim, Mary Nabity, Joseph Rutkowski
Life of this patent
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Abstract
The present invention relates to a method for reducing blood pressure by stimulating lymphatic vessel growth and/or lymphangiogenesis in the kidneys.
Claims27
A method of treatment of a subject comprising:
- (a) providing a drug delivery vehicle comprising a carrier and a composition that stimulates lymphatic vessel growth, wherein said drug delivery vehicle delivers drug to the kidney;
- and
- (b) treating said subject by administering said drug delivery vehicle under conditions such that lymphatic vessel growth is stimulated in one or more of the kidneys of said subject.
A method of inducing renal lymphangiogenesis, comprising:
- (a) providing a drug delivery vehicle comprising a nanoparticle and composition comprising VEGF-C with a c156s mutation, wherein said drug delivery vehicle delivers said composition to the kidney;
- and
- (b) treating said subject by administering said drug delivery vehicle under conditions such that renal lymphangiogenesis is induced in one or more of the kidneys of said subject.
Dependencies are inferred from the claim text.