Methods and Compositions for Treating Neurodegeneration and Fibrosis
OwnerJohn W. Elrod, Pooja Jadiya +2inventors
InventorsJohn W. Elrod, Pooja Jadiya, Alyssa A. Lombardi, Timothy S. Luongo
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Abstract
This invention is generally related to novel compositions and methods for treating or preventing fibrosis, diseases or disorders associated with fibrosis, neurodegeneration, diseases or disorders associated with neurodegeneration and cardiovascular disease or disorders.
Claims16
A method for treating or preventing neurodegeneration or a neurodegeneration-related disease or disorder the method comprising administering a composition comprising an activator of mitochondrial Na+/Ca2+ exchanger (mNCX) to a subject in need thereof.
A method for treating or preventing fibrosis or a fibrosis-related disease or disorder the method comprising administering a composition comprising an modulator of a target to a subject in need thereof, wherein the target is selected from the group consisting of mitochondrial Na+/Ca2+ exchanger (mNCX), a PDH kinase, a PDH phosphatase, an alpha-ketoglutarate dependent demethylase, phosphofructokinase-2 (PFK-2), calcium sensitive alpha-ketoglutarate dehydrogenase, and the ratio of alpha-ketoglutarate to succinate.
A method for treating or preventing neurodegeneration or a cardiovascular disease or disorder the method comprising administering a composition comprising a modulator of mitochondrial Na+/Ca2+ exchanger (mNCX) to a subject in need thereof
Dependencies are inferred from the claim text.