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US 2021/0330738 A1Published application
Antimicrobial, bacteriophage-derived polypeptides and their use against gram-negative bacteria
OwnerRaymond SCHUCHinventor
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OwnerRaymond SCHUCHinventor
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Disclosed herein are pharmaceutical compositions comprising an effective amount of an isolated Chp peptide having an amino acid sequence selected from the group consisting of SEQ ID NOs. 1-4, 6-26 and 54-66, or a modified Chp peptide having about 80% sequence identity therewith, wherein the modified Chp peptide inhibits growth, reduces the population, or kills at least one species of Gram-negative bacteria; and a pharmaceutically acceptable carrier. Further disclosed herein are isolated Chp peptides, as well as vectors comprising a nucleic acid molecule that encode the Chp peptides and host cells comprising a vector. Also disclosed herein are methods of inhibiting the growth, reducing the population, or killing of at least one species of Gram-negative bacteria and methods of treating a bacterial infection in a subject.
A pharmaceutical composition comprising:
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A vector comprising a nucleic acid molecule that encodes (i) a Chp peptide having an amino acid sequence selected from the group consisting of SEQ ID NOs. 1-4, 6-26 and 54-66 or active fragments thereof, or (ii) a modified Chp peptide having 80% sequence identity with the amino acid sequence of at least one of SEQ ID NOs. 1-4, 6-26 and 54-66, wherein the modified Chp peptide inhibits the growth, or reduces the population, or kills at least one species of Gram-negative bacteria.
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An isolated, purified nucleic acid encoding a Chp peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs. 1-4, 6-26 and 54-66 or active fragments thereof or a nucleic acid comprising a sequence complementary thereto, wherein the Chp peptide contains at least one non-natural modification relative to the amino acid sequence of any one of SEQ ID NOs. 1-4, 6-26 and 54-66 or active fragments thereof.
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An isolated, purified DNA comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs. 27-30, SEQ ID NOs. 32-53, and SEQ ID NOs. 68-79 wherein the nucleotide sequence contains at least one non-natural modification.
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A method of inhibiting the growth, reducing the population, or killing of at least one species of Gram-negative bacteria, the method comprising contacting the bacteria with a composition comprising an effective amount of (i) a Chp peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NOs. 1-4, 6-26 and 54-66 or active fragments thereof, or (ii) a modified Chp peptide having 80% sequence identity with the amino acid sequence of at least one of SEQ ID NOs. 1-4, 6-26 and 54-66, said Chp peptide or modified Chp peptide having lytic activity for a period of time sufficient to inhibit said growth, reduce said population, or kill said at least one species of Gram-negative bacteria.
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Dependencies are inferred from the claim text.