Tetrathionate for Cyanide and Methylmercaptan Poisoning
AssigneesThe Regents of the University of California, The Regents of the University of Colorado
InventorsGerry R. Boss, Adriano Chan, Matthew Brenner, Sari Brenner Mahon, Vikhyat Bebarta
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Abstract
Provided is a method, and pharmaceutical composition, to treat or prevent cyanide poisoning and/or methylmercaptan poisoning comprising administering to a subject in need an effective amount of tetrathionate by intramuscular injection or by intranasal administration. Also provided is a method for detecting the presence of tetrathionate in a sample by reacting it with cyanide and measuring the resulting thiocyanate with ferric nitrate.
Claims18
A method of treating or preventing cyanide poisoning or methylmercaptan poisoning in a subject comprising administering to a subject in need an effective amount of tetrathionate by intranasal instillation.
A method of treating or preventing cyanide poisoning or methylmercaptan poisoning in a subject comprising administering to a subject in need an effective amount of tetrathionate by intramuscular injection.
A method of measuring tetrathionate in a biological sample comprising:
- reacting the biological sample with cyanide to produce thiocyanate;
- reacting the thiocyanate with ferric nitrate;
- and
- detecting a colorimetric change indicating the presence of tetrathionate in the sample.
Dependencies are inferred from the claim text.