Method Of Treating Inflammation
AssigneeCytoSorbents Corporation
InventorsPhillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
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Abstract
The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
Claims22
A method of prophylactically treating systemic, regional, or local inflammation from a patient at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent for an inflammatory mediator in said patient;
- wherein the sorbent is a biocompatible polymer comprises:
- (i) cross-linked, porous styrene or divinylbenzene copolymer;
- or
- (ii) cross-linked, porous styrene or divinylbenzene copolymer, where the cross-linked, porous styrene or divinylbenzene copolymer copolymer is:
- (a) macroporous or mesoporous styrene-divinylbenzene-ethyl styrene copolymer submitted to a partial chloromethylation to a 7% molecular chlorine content;
- or
- (b) cross-linked polystyrene produced by crosslinked styrene copolymers through an extensive chloromethylation and a subsequent post-crosslinking through treatment with a Friedel-Crafts catalyst in a swollen state;
- or
- (c) cross-linked polystyrene produced from cross-linked styrene copolymer through an extensive additional post-cross-linking in a swollen state with difunctional cross-linking agents selected from the group which comprises monochlorodimethylether and dicloroparaxylene.
Dependencies are inferred from the claim text.