Treatment of pain with polysulfated polysaccharides
AssigneeParadigm Biopharmaceuticals Ltd
InventorsPaul Rennie, Ravi Krishnan
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Abstract
The present disclosure relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions. In particular, the disclosure relates to use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions mediated by mature Nerve Growth Factor (NGF) or its precursor pro-Nerve Growth Factor (pro-NGF).
Claims36
A method of inhibiting or reducing Nerve Growth Factor (NGF) or pro-Nerve Growth Factor (pro-NGF) activity in a mammal, the method comprising the step of administering a polysulfated polysaccharide or an acceptable salt thereof, to the mammal.
Use of a polysulfated polysaccharide or an acceptable salt thereof, in inhibiting or reducing Nerve Growth Factor (NGF) or pro-Nerve Growth Factor (pro-NGF) activity in a mammal.
Use of a polysulfated polysaccharide or an acceptable salt thereof, in the manufacture of a medicament for inhibiting or reducing Nerve Growth Factor (NGF) or pro-Nerve Growth Factor (pro-NGF) activity in a mammal.
A method of treating pain mediated by Nerve Growth Factor (NGF) or pro-Nerve Growth Factor (pro-NGF), the method comprising the step of administering a polysulfated polysaccharide or an acceptable salt thereof, to a mammal in need of such treatment.
Use of a polysulfated polysaccharide or an acceptable salt thereof, in treating pain mediated by Nerve Growth Factor (NGF) or pro-Nerve Growth Factor (pro-NGF) in a mammal.
Use of a polysulfated polysaccharide or an acceptable salt thereof, in the manufacture of a medicament for treating pain mediated by Nerve Growth Factor (NGF) or pro-Nerve Growth Factor (pro-NGF) in a mammal.
Dependencies are inferred from the claim text.