US 2021/0330689 A1 · COMPOSITION FOR TREATING BLOOD CANCER USING 4'-THIO-5-AZA-2'-DEOXYCYTIDINE AND USES THEREOF

Abstract

The present invention relates to pharmaceutical compositions for treating blood cancer, which includes 4′-thio-5-aza-2′-deoxycytidine (Aza-T-dCyd), and methods of treating blood cancer using a composition for oral administration that includes Aza-T-dCyd. The present invention provides a significant blood cancer therapeutic effect without having toxicity in a blood cancer mouse model or a human even with the Aza-T-dCyd dose conventionally known to have toxicity. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Claims20

Dependent claims

A pharmaceutical composition comprising a therapeutically effective amount of a compound having a structure:

and a pharmaceutically acceptable carrier,
wherein the therapeutically effective amount is of from about 5 mg/m2 to no more than about 70 mg/m2, and
wherein the pharmaceutical composition is formulated for oral administration.

Dependencies are inferred from the claim text.

Facts

Application

17/238,182Filed 22 Apr 2021

Priority

23 Apr 2020

Published

28 Oct 2021

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 31/53
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with three nitrogens as the only ring hetero…
A61K 31/706
Having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides: containing six-membered rings with nitrogen as a ring hetero atom
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration
A61K 31/635
Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide: having a heterocyclic ring, e.g.…

Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof

Life of this patent

Composition for treating blood cancer using 4'-thio-5-aza-2'-deoxycytidine and uses thereof

Life of this patent

Abstract

Claims20