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US 2021/0330682 A1Published application
Compositions and methods for delivering therapeutic agents into the colon
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSidhartha Ranjit SINHA, Jayakumar RAJADAS, Aida HABTEZION, Ravinder D. PAMNANI
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Abstract
Enema compositions containing corticosteroids or salicylic acid derivatives are disclosed. The compositions are liquid at room temperature but turn to gels at body temperature. They are useful for treating inflammatory bowel disease.
Claims21
1-18. (canceled)
A method of making an enema composition, the method comprising:
- combining an active agent in a dry, non-aqueous form with water, a thermo-active polymer, and one or more lipids to produce a lipidic suspension into which the active agent is dispersed, thereby creating an enema composition.
The method of claim 1280, wherein the enema composition comprises the salicylic acid derivative at from 50 g/L to 100 g/L.
Dependencies are inferred from the claim text.