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US 2021/0330674 A1Published application
Deuterated derivatives of ruxolitinib
AssigneeConcert Pharmaceuticals, Inc.
InventorsI. Robert Silverman, Julie F. Liu, Adam J. Morgan, Bhaumik Pandya, Scott L. Harbeson
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Abstract
The present invention in one embodiment provides a compound of Formula A: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising the compound; and methods of treating the indications disclosed herein.
Claims14
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- Y6, Y7 and Y8 are each hydrogen, and the compound is selected from any one of the compounds set forth in the table below:
- Cmpd
- Y1
- Each Y2
- Each Y3
- Y4
- each Y5
- 100
- H
- H
- H
- D
- H
- 101
- H
- H
- H
- H
- D
- 102
- H
- H
- H
- D
- D
- 103
- H
- H
- D
- H
- H
- 104
- H
- H
- D
- D
- H
- 105
- H
- H
- D
- H
- D
- 106
- H
- H
- D
- D
- D
- 107
- H
- D
- H
- H
- H
- 108
- H
- D
- H
- D
- H
- 109
- H
- D
- H
- H
- D
- 110
- H
- D
- H
- D
- D
- 111
- H
- D
- D
- H
- H
- 112
- H
- D
- D
- D
- H
- 113
- H
- D
- D
- H
- D
- 114
- H
- D
- D
- D
- D
- 115
- D
- H
- H
- H
- H
- 116
- D
- H
- H
- D
- H
- 117
- D
- H
- H
- H
- D
- 118
- D
- H
- H
- D
- D
- 119
- D
- H
- D
- H
- H
- 120
- D
- H
- D
- D
- H
- 121
- D
- H
- D
- H
- D
- 122
- D
- H
- D
- D
- D
- 123
- D
- D
- H
- H
- H
- 124
- D
- D
- H
- D
- H
- 125
- D
- D
- H
- H
- D
- 126
- D
- D
- H
- D
- D
- 128
- D
- D
- D
- D
- H
- 129
- D
- D
- D
- H
- D
- 130
- D
- D
- D
- D
- D
- wherein any atom not designated as deuterium is present at its natural isotopic abundance.
186 more elements
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- Y6, Y7 and Y8 are each deuterium, and the compound is selected from any one of the compounds set forth in the table below:
- Cmpd
- Y1
- Each Y2
- Each Y3
- Y4
- each Y5
- 200
- H
- H
- H
- D
- H
- 201
- H
- H
- H
- H
- D
- 202
- H
- H
- H
- D
- D
- 203
- H
- H
- D
- H
- H
- 204
- H
- H
- D
- D
- H
- 205
- H
- H
- D
- H
- D
- 206
- H
- H
- D
- D
- D
- 207
- H
- D
- H
- H
- H
- 208
- H
- D
- H
- D
- H
- 209
- H
- D
- H
- H
- D
- 210
- H
- D
- H
- D
- D
- 211
- H
- D
- D
- H
- H
- 212
- H
- D
- D
- D
- H
- 213
- H
- D
- D
- H
- D
- 214
- H
- D
- D
- D
- D
- 215
- D
- H
- H
- H
- H
- 216
- D
- H
- H
- D
- H
- 217
- D
- H
- H
- H
- D
- 218
- D
- H
- H
- D
- D
- 219
- D
- H
- D
- H
- H
- 220
- D
- H
- D
- D
- H
- 221
- D
- H
- D
- H
- D
- 222
- D
- H
- D
- D
- D
- 223
- D
- D
- H
- H
- H
- 224
- D
- D
- H
- D
- H
- 225
- D
- D
- H
- H
- D
- 226
- D
- D
- H
- D
- D
- 227
- D
- D
- D
- H
- H
- 228
- D
- D
- D
- D
- H
- 229
- D
- D
- D
- H
- D
- 230
- D
- D
- D
- D
- D
- 231
- H
- H
- H
- H
- H
- wherein any atom not designated as deuterium is present at its natural isotopic abundance.
198 more elements
Dependencies are inferred from the claim text.