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US 2021/0330662 A1Published application
Quinolylnitrones for the treatment and prevention of a cerebral stroke or ischaemia
AssigneesConsejo Superior De Investigaciones Cientificas (Csic), FundacióN Para La InvestigacióN BioméDica Del Hospital Ramon Y Cajal (Fibiohrc), Isquaemia Biotech, S.L.
InventorsAlberto ALCÁZAR GONZÁLEZ, Emma MARTÍNEZ ALONSO, José Luis MARCO CONTELLES, Mourad CHIOUA ASRI, Juan José MONTOYA
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Abstract
The invention relates to neuroprotective, antioxidant quinolylnitrones to which the blood-brain barrier is highly permeable, as potential drugs for the treatment of a cerebral stroke or ischaemia, Alzheimer's and Parkinson's disease and amyotrophic lateral sclerosis.
Claims5
A quinolylnitrone of formula I,
- wherein the compound of formula I is (Z)—N-t-butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine oxide or salts and hydrates thereof;
- for use in the prevention and/or treatment of cerebral stroke or ischaemia.
Dependencies are inferred from the claim text.