Formulations for cgrp receptor antagonists
OwnerMajid Mahjour, Leonardo R. Allain +6inventors
InventorsMajid Mahjour, Leonardo R. Allain, Sutthilug Sotthivirat, Russell G. Maus, Rebecca Nofsinger, Lisa Lupton, Wei Xu, Francis Flanagan
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Abstract
The instant invention relates to liquid pharmaceutical compositions containing CGRP receptor antagonists. The CGRP receptor antagonist liquid pharmaceutical compositions of the instant invention are alcohol-free, low volume liquid pharmaceutical compositions that can be taken without water for the treatment of migraine headache.
Claims19
A liquid pharmaceutical composition comprising (S)-N-((3S, 5S, 6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidine-3-yl)-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3-b]pyridine]-3-carboxamide trihydrate present in an amount of 0.25% to 2% by weight of the composition, and a pharmaceutically acceptable carrier comprising VitE-TPGS, polyvinylpyrrolidone, PEG 400, and propylene glycol.
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Dependencies are inferred from the claim text.