Spirochromane derivatives
AssigneeRichter Gedeon Nyrt.
InventorsJános ÉLES, Katalin DUDÁSNÉ MOLNÁR, István LEDNECZKI, Pál TOPOLCSÁNYI, Anita HORVÁTH, Zsolt NÉMETHY, György István LÉVAY
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Abstract
The invention relates to spirochromane derivatives, or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof, as well as to pharmaceutical compositions containing them and to their use as modulators of α7 nicotinic acetylcholine receptor activity in a mammalian subject.
Claims24
A compound of formula (I),
- wherein:
- A is a five or six membered heterocycle;
- B is a six membered carbocycle or heterocycle;
- X is C or N;
- Y is C or N;
- Z is C or N;
- W is O or S;
- R1 is H, C1-6alkyl, halogen or haloC1-6alkyl;
- R2 is H or O;
- R3 is H, C1-6alkyl, halogen, haloC1-6alkyl or C1-6alkoxy;
- R4 is H or C1-6alkyl;
- R5 is H or C1-6alkyl;
- n and m are independently 1 or 2;
- is a single- or double-bond;
- or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof.
A compound of formula (II),
- wherein
- V is C or S;
- Z is C or N
- W is O or S;
- R1a is H, C1-6alkyl, or haloC1-6alkyl;
- R1b is H, C1-6alkyl, halogen, or haloC1-6alkyl;
- R1c is H, C1-6alkyl, halogen, or haloC1-6alkyl when V is carbon;
- or R1c is absent when
- V is sulphur;
- R2 is H or O;
- R3 is H, C1-6alkyl, halogen, haloC1-6alkyl, or C1-6alkoxy;
- n and m are independently 1 or 2;
- is a single- or double-bond;
- or pharmaceutically acceptable salts, biologically active metabolites, pro-drugs, racemates, enantiomers, diastereomers, solvates and hydrates thereof.
A compound of (1,2-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanamine.
A compound of {3-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl}methanamine.
A compound of {3-Bromo-1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl}methanamine.
A compound of 3′,4′-Dihydrospiro[azetidine-3,2′-pyrano[3,2-b]pyridin]-4′-one hydrochloride.
Dependencies are inferred from the claim text.