Compositions for the prevention and treatment of acute renal injury
AssigneeAKI Therapeutics ApS
InventorLars Otto Uttenthal
Life of this patent
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Abstract
Pharmaceutical compositions are provided for the treatment, pre-emptive treatment or prevention of acute renal injury.
Claims14
A composition comprising a drug chosen from a cyclosporin, tacrolimus, serolimus or everolimus, wherein said drug is conjugated to a neutrophil gelatinase-associated lipocalin (NGAL) or to a lysozyme or to a low-molecular-weight chitosan, and wherein the conjugate is formulated for intravenous administration to a human subject.
2-14. (canceled)
A composition comprising a combination of drugs formulated for intravenous administration to a human subject, the combination of drugs comprising celastrol or pristimerin or betulinic acid in combination with a saponin or flavonoid chosen from diosmin, hesperidin or saponins from Panax quinquefolium.
Dependencies are inferred from the claim text.