Nano-penetrative cannabinoid oil blends and compositions and methods of formulation thereof

A cavitated therapeutic oil blend comprising:

• a) 25-75% w/w cannabinoid content;
• and
• b) 25-75% w/w terpene content,
• wherein the cavitated therapeutic oil blend has an average cannabinoid crystal size of less than 300 nm at room temperature, wherein the cavitated therapeutic oil blend comprises cavitation bubbles, and wherein weight contents are calculated based on the weight of the cavitated therapeutic oil blend.

A cavitated therapeutic oil blend that comprises:

• a) 25-90% w/w cannabidiol content;
• b) 25%-75% w/w terpene content, wherein the terpene content comprises:
• i) clove bud oil;
• ii) peppermint oil;
• or
• iii) both i) and ii),
• wherein the cavitated therapeutic oil blend has an average cannabinoid crystal size of less than 300 nm at room temperature, wherein the cavitated therapeutic oil blend comprises cavitation bubbles, and wherein weight contents are calculated based on the weight of the cavitated therapeutic oil blend.

A method of preparing a cavitated therapeutic oil blend, the method comprising:

• a) heating a cannabinoid under conditions sufficient to melt or dissolve the cannabinoid, thereby producing a liquid cannabinoid;
• b) admixing:
• i) 25-75% w/w liquid cannabinoid;
• and
• ii) 25-75% w/w terpene, thereby producing a mixture;
• and
• c) cavitating the mixture of step (b) under conditions sufficient to generate cavitation bubbles, thereby generating the cavitated therapeutic oil blend, wherein the cavitated therapeutic oil blend has an average cannabinoid crystal size of less than 300 nm at room temperature, and wherein weight contents are calculated based on the weight of the cavitated therapeutic oil blend.