Pharmaceutical Compositions Comprising Dimethyl Fumarate
OwnerMaria PLANELLS JIMENEZ, Begoña DUARTE LOPEZ +1inventors
InventorsMaria PLANELLS JIMENEZ, Begoña DUARTE LOPEZ, Pere GUIRO COLL
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Abstract
Pharmaceutical compositions are described comprising (a) dimethyl fumarate, (b) a diluent selected from monosaccharides, disaccharides, starch and starch derivatives, calcium and magnesium inorganic salts, sugar alcohols, and mixtures thereof, (c) microcrystalline cellulose and (d) croscarmellose sodium, wherein the dimethyl fumarate is not covered with a gastro-resistant coating. These compositions are intended for the treatment of some inflammatory autoimmune diseases or disorders.
Claims11
A pharmaceutical composition in the form of a gastro-resistant tablet, which pharmaceutical composition is enteric-coated and comprises, based on the total weight of the tablet previous to coating:
- (a) 20-30 wt. % of dimethyl fumarate;
- (b) 25-35 wt. % of a diluent selected from lactose, D-glucose (dextrose), sucrose, fructose, galactose, calcium carbonate, dibasic calcium phosphate, calcium sulphate, magnesium carbonate, isomalt, mannitol, maltitol, sorbitol, xylitol, and mixtures thereof;
- (c) 35-45 wt. % of microcrystalline cellulose;
- (d) 1-10 wt. % of croscarmellose sodium;
- and
- wherein the dimethyl fumarate is not covered with a gastro-resistant coating.
2-4. (canceled)
9-14. (canceled)
16-18. (canceled)
Dependencies are inferred from the claim text.