Process for manufacturing phenylephrine resinate particles; phenylephrine resinate particles; and use of phenylephrine resinate particles in pharmaceutical formulations

A process for preparing a drug-resin complex, comprising:

• Step A:
• mixing purified water and resin in a container to form a first mixture;
• filtering the first mixture to form a wet cake containing resin;
• rinsing the wet cake containing resin with purified water;
• filtering the rinsed wet cake containing resin;
• Step B:
• mixing purified drug and water in a container to form a drug solution;
• Step C:
• mixing the filtered wet cake containing resin and a portion of the drug solution in a container to form a second mixture;
• filtering the second mixture to form a first loaded resinate;
• Step D:
• mixing the first loaded resinate and a portion of the drug solution in a container to form a third mixture;
• filtering the third mixture to form a second loaded resinate;
• Step E:
• optionally, repeating step D multiple times;
• and
• Step F:
• drying the loaded resinate to form the drug-resin complex.