Therapy for neurological diseases/disorders
OwnerKaterina Akassoglou, Anke Meyer-Franke +3inventors
InventorsKaterina Akassoglou, Anke Meyer-Franke, Alex Pico, Kean-Hooi Ang, Michelle Rose Arkin
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Abstract
Provided herein are compositions and methods to treat or prevent neurodegeneration in a mammal, inhibit microglial activation in the CNS of a mammal, promote survival of CNS neurons in a mammal, prevent or reduce the rate of demyelination and/or neuronal injury in a mammal, promote remyelination in a mammal and/or treat or prevent or decrease oxidative stress in a mammal.
Claims20
A method to treat or prevent neurodegeneration in a mammal comparing administering to said mammal an effect amount of a composition comprising a modulator of calcium signaling, a modulator of microtubule dynamics, a modulator of chemokine signaling, a modulator of DNA replication, a modulator of dopamine receptor signaling, a modulator of cAMP signaling, a modulator of glucocorticoid-receptor signaling, a modulator of purine nucleotide biosynthesis, a modulator of neurotransmitter transport or a combination thereof or one or more of the small molecules provided in Table 1 and/or Table 2, provided that the small molecule is not acivicin.
A method for inhibiting microglial activation in the CNS of a mammal and/or promoting survival of CNS neurons in a mammal, comprising administering to a mammal in need thereof an effective amount of a composition comprising a modulator of calcium signaling, a modulator of microtubule dynamics, a modulator of chemokine signaling, a modulator of DNA replication, a modulator of dopamine receptor signaling, a modulator of cAMP signaling, a modulator of glucocorticoid-receptor signaling, a modulator of purine nucleotide biosynthesis, a modulator of neurotransmitter transport or a combination thereof.
A method for preventing or reducing the rate of demyelination and/or neuronal injury in a mammal and/or promoting remyelination in a mammal and/or treating or preventing or decreasing oxidative stress in a mammal in need thereof comprising administering to the mammal an effective amount of a modulator of calcium signaling, a modulator of microtubule dynamics, a modulator of chemokine signaling, a modulator of DNA replication, a modulator of dopamine receptor signaling, a modulator of cAMP signaling, a modulator of glucocorticoid-receptor signaling, a modulator of purine nucleotide biosynthesis, a modulator of neurotransmitter transport or a combination thereof.
Dependencies are inferred from the claim text.