Compositions and methods for treating seizure-induced sudden death
AssigneeZogenix International Limited
InventorParthena Martin
Life of this patent
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Abstract
5-HT receptor agonists are useful in the treatment of a variety of diseases. Provided herein are methods of reducing the incidence and/or severity of seizures in a human patient using a 5-HT receptor agonist, such as, for example, a 5-HT4 agonist (e.g., fenfluramine). Methods of treating epilepsy or epileptic encephalopathy, and/or reducing, ameliorating or eliminating incidence of SUDEP in a subject diagnosed with epilepsy by administering a 5-HT4 agonist (e.g., fenfluramine) to a subject in need thereof are provided. Pharmaceutical compositions for use in practicing the subject methods are also provided.
Claims21
1-24. (canceled)
A method of reducing likelihood of seizure-induced Sudden Unexpected Death in Epilepsy (SUDEP) in a human patient, comprising:
- administering to the patient a therapeutically effective dose of a 5-HT4 agonist;
- and
- allowing the 5-HT4 agonist to stimulate 5-HT4 receptors in the patient, thereby reducing the likelihood of SUDEP in the patient.
A method of reducing the length of the mean post-ictal depression (PID) period in a human patient, comprising:
- administering to the patient a therapeutically effective dose of a 5-HT4 agonist;
- and
- allowing the 5-HT4 agonist to stimulate 5-HT4 receptors in the patient, thereby inhibiting PID period in the patient.
Dependencies are inferred from the claim text.