Halogenated ether compounds and methods of inducing anesthesia
AssigneeThe Regents of the University of California
InventorRobert J. Brosnan
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Abstract
A method of inducing anesthesia in a subject is provided. In some embodiments, the method provides administering to the subject via the respiratory system or via injection, an effective amount of a compound or a mixture of compounds selected from the group consisting of methyl-ethyl ethers, methyl-isopropyl ethers, and methyl-propyl ethers.
Claims11
1-4. (canceled)
A method for inducing anesthesia in a subject by potentiating GABAA receptors without inhibiting NMDA receptors, comprising administering to the subject via the respiratory system or via injection, an effective amount of a compound ethane, 1-bromo-1,1,2-trifluoro-2-(trifluoromethoxy)- (CAS #2356-55-0), thereby inducing anesthesia in the subject by potentiating GABAA receptors without inhibiting NMDA receptors.
9-16. (canceled)
A method for inducing anesthesia in a subject, the method comprising administering to the subject via the respiratory system or via injection, an effective amount of a compound or a mixture of compounds selected from the group consisting of a halogenated methyl-ethyl ether, a halogenated methyl-isopropyl ether, and a halogenated methyl-propyl ether, wherein the halogenated methyl-ethyl ether is selected from the group consisting of:
- Ethane, 1-(chlorodifluoromethoxy)-1,1,2,2,2-pentafluoro- (CAS #276640-96-1);
- Ethane, 2-bromo-1,1,1-trifluoro-2-(trifluoromethoxy)- (CAS #84011-04-1);
- Ethane, 1-bromo-1,2,2-trifluoro-1-(trifluoromethoxy)- (CAS #885275-60-5);
- Ethane, 2-bromo-1,1,2-trifluoro-1-(trifluoromethoxy)-(CAS #84011-03-0);
- Ethane, 1-bromo-1,1,2-trichloro-2-(trifluoromethoxy)- (CAS #2356-55-0):
- Ethane, 2-chloro-1,1,2-trifluoro-1-(trifluoromethoxy)- (CAS #879885-11-7);
- Ethane, 2-chloro-1,1,1-trifluoro-2-(trifluoromethoxy)- (CAS #,94720-92-0);
- Ethane, 1-chloro-1,1,2-trifluoro-2-(trifluoromethoxy)- (CAS #2356-59-4);
- Ethane, 1-chloro-1,1-difluoro-2-(trifluoromethoxy)-(CAS #1645-80-3);
- Ethane, 1-chloro-1,2-difluoro-2-(trifluoromethoxy)-, (R*,S*)- (9CI) (CAS #84011-29-0);
- Ethane, 1-chloro-1,2-difluoro-2-(trifluoromethoxy)-(R*,R*)- (9CI) (CAS #84011-28-9);
- Ethane, 1-chloro-1,2-difluoro-2-(trifluoromethoxy)- (CAS #54362-39-9);
- Ethane, 1-chloro-2,2-difluoro-1-(trifluoromethoxy)- (CAS #33445-33-9);
- and mixtures thereof;
- wherein the halogenated methyl-isopropyl ether is selected from the group consisting of:
- Propane, 1-chloro-1,1,2,3,3,3-hexafluoro-2-(trifluoromethoxy)- (CAS #41255-97-4);
- Propane, 1,1,1,2,3,3,3-heptafluoro-2-(trifluoromethoxy)- (CAS #60901-74-8);
- Propane, 1,1,1,3,3,3-hexafluoro-2-(trifluoromethoxy)- (CAS #162401-05-0);
- Propane, 2- (difluoromethoxy)-1,1,1,2,3,3-hexafluoro-(CAS #233258-12-3), and mixtures thereof;
- and wherein the halogenated methyl-propyl ether is selected from the group consisting of:
- Propane, 1,1,2,2,3,3-hexafluoro-1-methoxy-(CAS #160620-20-2);
- Propane, 1,1,1,2,2,3-hexafluoro-3-methoxy- (CAS #123202-00-6);
- Propane, 1,1,1,2,3,3-hexafluoro-3-(fluoromethoxy)- (CAS #60598-14-3);
- Propane, 3-(difluoromethoxy)-1,1,1,2,2-pentafluoro- (CAS #56860-81-2);
- Propane, 1,1,1,2,2-pentafluoro-3-(fluoromethoxy)- (CAS #1515-13-5);
- and mixtures thereof.
Dependencies are inferred from the claim text.