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AssigneesUniversity of Rochester, The Trustees of the University of Pennsylvania
InventorsDanielle BENOIT, Hyun KOO
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The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed.
A composition comprising at least one nanoparticle carrier (NPC) having a poly(dimethylaminoethyl methacrylate) (pDMAEMA) shell and a poly(dimethylaminoethyl methacrylate-co-propylacrylic acid-co-butyl methacrylate) (p(DMAEMA-co-PAA-co-BMA)) core, wherein the at least one NPC comprises a shell-to-core molecular weight ratio between 1 and 12, and wherein the core comprises a therapeutically effective amount of at least one therapeutic agent.
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A composition comprising a shell and a core, the shell comprising a material selected from the group consisting of:
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Dependencies are inferred from the claim text.