Loading patent…
AssigneeChildren's Medical Center Corporation
InventorsDaniel S. Kohane, Tianjiao Ji, Christopher B. Weldon
Estimating the term…
Compositions and methods of use related to formulations comprising anesthetics are generally described. Some embodiments are directed to compositions comprising a plurality of micelles and/or particles, and an anesthetic contained internally. These can be used to control and/or prolong the duration of IVRA while reducing the risk of systemic toxicity commonly due to administering anesthetics. The control and/or prolonged duration of IVRA may be due, at least in part, to the attachment of the sufficiently small micelles and/or particles to a biointerface (e.g., blood vessel surface) where the composition has been administered. Conventional IVRA methods commonly do not utilize potent and long-acting anesthetics (e.g., bupivacaine) due to the risks of cardiac toxicity. The compositions and methods described herein, however, provide a pathway for increased safety and efficiency of the use of such anesthetics, in certain embodiments. Resultantly, the performance (e.g., anesthetic distribution) of the micelles and/or particles internally containing an anesthetic may be comparatively better than the performance of free anesthetic, e.g., with respect to nerve blood and systematic drug distribution.
A composition, comprising:
The composition of any one of the preceding claims, wherein the PEGylated lipids and/or polymers comprise DSPE-PEG, DPPE-PEG, DMPE-PEG, PEG-PLGA, and/or PEG-PLA.
The composition of any one of the preceding claims, wherein the PEGylated lipids and/or polymers have a molecular weight in the range of 200 Daltons to 5,000 Daltons.
The composition of any one of the preceding claims, wherein the PEGylated lipids and/or polymers comprise DSPE-PEG(2000).
The composition of any one of the preceding claims, wherein the micelles and/or particles have an average cross-sectional diameter of less than or equal to 20 nm.
The composition of any one of the preceding claims, wherein the micelles and/or particles have an average cross-sectional diameter of less than or equal to 15 nm.
The composition of any one of the preceding claims, wherein the anesthetic is a local anesthetic.
The composition of any one of the preceding claims, wherein the anesthetic is an amide-containing anesthetic.
The composition of any one of the preceding claims, wherein the anesthetic is an amino-amide anesthetic.
The composition of any of the preceding claims, wherein the anesthetic comprises articaine, bupivacaine, cinchocaine, etidocaine, levobupivacaine, lidocaine, mepivacaine, prilocaine, ropivacaine, and/or trimecaine.
The composition of any one of the preceding claims, wherein the anesthetic is bupivacaine.
The composition of any one of the preceding claims, wherein the anesthetic is lidocaine.
The composition of any one of the preceding claims, wherein the composition comprises an additive.
The composition of any one of the preceding claims, wherein the composition comprises the anesthetic in an amount of greater than or equal to 10 wt. %.
The composition of any one of the preceding claims, wherein the composition comprises bupivacaine in an amount of greater than or equal to 10 wt. %.
The composition of any one of the preceding claims, wherein the composition has a surface area-to-volume ratio of greater than about 0.10 and less than about 0.70.
The composition of any one of the preceding claims, wherein the composition is formulated via film dispersion.
A composition, comprising:
A method of delivering an anesthetic to a subject, comprising:
A method of delivering an anesthetic to a subject, comprising:
A method of delivering a drug to a subject, comprising:
A method of delivering a drug to a subject, comprising:
Dependencies are inferred from the claim text.